التفاصيل البيبلوغرافية
| العنوان: |
Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients. |
| المؤلفون: |
Borgo Sarmento, Estéfano, Helena Teixeira de Lima Ribeiro Andrade, Rosana, Cristina Gomes, Cinthya, Ramôa Pires, Fábio, Bastos Valente, Maria Isabel, Mafra Moreno, Adalgiza, Orsini, Marco, Carvalho Ferreira, Dennis, Souza Gonçalves, Lucio, Armada, Luciana |
| المصدر: |
International Journal of Dentistry; 2/10/2023, p1-6, 6p |
| مصطلحات موضوعية: |
PERIAPICAL periodontitis, PEOPLE with diabetes, CYTOKINES, BONE resorption, INTERLEUKIN-17 |
| مستخلص: |
Diabetes mellitus has been regarded as a condition capable of influencing the evolution of periapical lesions. Therefore, this study evaluated the immunoexpression of IL-1β, TNF-α, and IL-17 in apical periodontitis from type 2 diabetic patients through immunohistochemistry. Twenty-six periapical lesions were selected, and the images obtained through immunohistochemistry reactions were analyzed. The statistical significance was set at p < 0.05. IL-1β expression was considered focal (54%), weak to moderate (38%), and strong (8%) in diabetics, and focal (46%), weak to moderate (31%), and strong (23%), in controls. TNF-α was focal (85%) and weak to moderate (15%) in diabetics, and focal (92%) and weak to moderate (8%), in controls. IL-17 was focal (8%), weak to moderate (46%), and strong (46%) in diabetics, and focal (62%), weak to moderate (8%), and strong (30%), in controls. The quantitative analysis revealed greater expression of IL-17, with a significant difference between IL-17 × IL-1β × TNF-α p = 0.0009 in the diabetic group. The cytokines IL-1β and TNF-α did not express statistical differences between the tested groups. The IL-17 showed higher immunoexpression in the diabetic group p = 0.047 , which may suggest higher bone resorption activity in chronic apical periodontitis in this group of patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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