التفاصيل البيبلوغرافية
| العنوان: |
Interleukin-32γ promotes macrophage-mediated chemoresistance by inducing CSF1-dependent M2 macrophage polarization in multiple myeloma. |
| المؤلفون: |
Yan, Haimeng, He, Donghua, Qu, Jianwei, Liu, Yang, Xu, Ruyi, Gu, Huiyao, Chen, Jing, Li, Yi, Zhang, Enfan, Zhao, Yi, He, Jingsong, Cai, Zhen |
| المصدر: |
Cancer Immunology, Immunotherapy; Feb2023, Vol. 72 Issue 2, p327-338, 12p |
| مصطلحات موضوعية: |
MULTIPLE myeloma, MACROPHAGE colony-stimulating factor, DRUG resistance in cancer cells, CD38 antigen, INTERLEUKIN-32, DRUG resistance |
| مستخلص: |
Macrophages (MΦs) are an abundant component in the multiple myeloma (MM) environment and contribute to MM drug resistance. We previously showed that interleukin-32 (IL-32) is highly expressed in MM patients and induces the immunosuppressive function of MΦs. The present study was designed to explore the role of IL-32 in MΦ-mediated MM drug resistance and the underlying mechanism. Our analysis revealed that IL-32 expression was upregulated in relapsed MM patients and associated with CD206+ M2 MΦ infiltration. Subsequently, we found that the most active isoform, IL-32γ, promoted MΦs to protect MM cells from drug-induced apoptosis both in vitro and in vivo. Furthermore, by evaluating many parameters, including surface markers, cytokines, metabolic enzymes and characteristic molecules, IL-32γ was verified to induce the polarization of M2 MΦs, a function that was partly dependent on increasing the expression of colony-stimulating factor 1 (CSF1). Taken together, the results of our study indicate that IL-32γ promotes MΦ-mediated MM drug resistance and modifies MΦs toward the M2 phenotype, providing a crucial theoretical basis for targeted MΦ immunotherapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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