التفاصيل البيبلوغرافية
| العنوان: |
Decrease in Mortality from Sepsis: Impact of the Multidisciplinary Program for the Hematologic Patient at Very High Risk. |
| المؤلفون: |
Basquiera, Ana L., Aguirre, María A., Serra, Florencia A., Vaca, Mayra, Brulc, Erika B., Perusini, María A., Ferini, Gonzalo A., Schutz, Natalia P., Otero, Victoria, García Corbanini, Damián, Litvack, Edgardo, Giron, Julio, Garnica, Gastón, Martinez, Bernardo, Michelangelo, Hernán, San Román, Eduardo, Pollán, Javier, Fantl, Dorotea B., Arbelbide, Jorge A., Valledor, Alejandra |
| المصدر: |
Indian Journal of Hematology & Blood Transfusion; Jan2023, Vol. 39 Issue 1, p7-14, 8p |
| مستخلص: |
A program for the hematologic patient at very high risk of infections (HAR, from its initials in Spanish) was implemented, based on a multidisciplinary team and six measures intended to reduce the colonization and subsequent sepsis by multidrug-resistant organisms (MDRO). We aimed at evaluating the effectiveness of the HAR program in terms of MDRO infections mainly caused by Klebsiella pneumoniae carbapenemase-producing and multidrug-resistant Pseudomona aeruginosa, and sepsis-related mortality. We established retrospective comparisons between the pre-HAR period (2016–2018) and the post-HAR period (2018–2019), in patients who received a hematopoietic stem cell transplant (HSCT) and/or intensive chemotherapy to treat non-M3 acute myeloid leukemia (CH-AML). We included 262 patients: 176 pre-HAR and 86 post-HAR. MDRO infection was 4.6% at 30 days and 6.1% at 90 days (all the cases during the pre-HAR period). Sepsis-related mortality was 6.5%, considering a median follow-up of 608 days: 6.1% in the HSCT group and 12.4% in the CH-AML group (p = 0.306). Sepsis-related mortality was 8.7% in the pre-HAR period and 0% in the post-HAR period (p = 0.014). The implementation of this multidisciplinary program based in preventive measures and the appropriate use of antibiotics enabled a decrease in sepsis-related mortality in very high-risk hematologic patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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