التفاصيل البيبلوغرافية
| العنوان: |
Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. |
| المؤلفون: |
Lin, Chin-Yu, Chung, Fa-Po, Nwe, Nwe, Hsieh, Yu-Cheng, Li, Cheng-Hung, Lin, Yenn-Jiang, Chang, Shih-Lin, Lo, Li-Wei, Hu, Yu-Feng, Tuan, Ta-Chuan, Chao, Tze-Fan, Liao, Jo-Nan, Chang, Ting-Yung, Kuo, Ling, Wu, Cheng-I, Liu, Chih-Min, Liu, Shin-Huei, Cheng, Wen-Han, Chen, Shih-Ann |
| المصدر: |
Journal of Clinical Medicine; Dec2022, Vol. 11 Issue 24, p7265, 11p |
| مصطلحات موضوعية: |
ARRHYTHMOGENIC right ventricular dysplasia, VENTRICULAR tachycardia, BODY surface mapping, ABLATION techniques, AMIODARONE |
| مستخلص: |
(1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was performed to achieve non-inducible VT. The patients were categorized into two groups according to whether they had used amiodarone before CA. Baseline and electrophysiological characteristics, substrate, and outcomes were compared. (3) Results: A total of 72 ARVC patients were studied, including 29 (40.3%) "off" amiodarone and 43 (56.7%) "on" amiodarone. The scar area was similar between the two groups. Patients "off" amiodarone had smaller endocardial and epicardial areas with abnormal electrograms. Twenty of 43 patients (47.5%) "on" amiodarone discontinued it within 3 months after CA. During a mean follow-up period of 43.2 ± 29.5 months, higher VT recurrence was observed in patients "on" amiodarone. Patients "on" amiodarone who discontinued amiodarone after CA had a lower recurrence than those without. (4) Conclusions: Patients with ARVC "on" amiodarone before CA had distinct substrate characteristics and worse ablation outcomes than patients "off" amiodarone, especially in those who had used amiodarone continuously. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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