التفاصيل البيبلوغرافية
| العنوان: |
Bee Venom Triggers Autophagy-Induced Apoptosis in Human Lung Cancer Cells via the mTOR Signaling Pathway. |
| المؤلفون: |
Yu, Ji Eun, Kim, Yuri, Hong, Da Eun, Lee, Dong Won, Chang, Ju Young, Yoo, Seung Sik, Kim, Min Ji, Son, Dong Ju, Yun, Jaesuk, Han, Sang-Bae, Hong, Jin Tae |
| المصدر: |
Journal of Oncology; 12/23/2022, p1-13, 13p |
| مصطلحات موضوعية: |
FLOW cytometry, STATISTICS, WASPS, CELL culture, AUTOPHAGY, WESTERN immunoblotting, IMMUNOHISTOCHEMISTRY, LUNG tumors, APOPTOSIS, MTOR inhibitors, PAIRED comparisons (Mathematics), CELLULAR signal transduction, CELL survival, ARTHROPOD venom, BEES, DESCRIPTIVE statistics, CELL lines, POLYMERASE chain reaction, HYDROXYCHLOROQUINE, DATA analysis, DATA analysis software, PHARMACODYNAMICS |
| مستخلص: |
In oriental medicine, bee venom has long been used as a therapeutic agent against inflammatory diseases. Several studies have reported that isolated and purified bee venom components are effective in treating dementia, arthritis, inflammation, bacterial infections, and cancer. In previous studies, we reported that bee venom inhibits cell growth and induces apoptotic cell death in lung cancer cells. In the present study, we assessed whether bee venom affects autophagy and thereby induces apoptosis. Bee venom treatment increased the levels of autophagy-related proteins (Atg5, Beclin-1, and LC3-II) and the accumulation of LC3 puncta. We found that bee venom could induce autophagy by inhibiting the mTOR signaling pathway. In addition, we found that hydroxychloroquine (HCQ)- or si-ATG5-induced autophagy inhibition further demoted bee venom-induced apoptosis. Bee venom-induced autophagy promotes apoptosis in lung cancer cells and may become a new approach to cancer treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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