التفاصيل البيبلوغرافية
| العنوان: |
Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: a meta-analysis of individual participant data. |
| المؤلفون: |
Liu, Enju, Wang, Dongqing, Darling, Anne M, Perumal, Nandita, Wang, Molin, Ahmed, Tahmeed, Christian, Parul, Dewey, Kathryn G, Kac, Gilberto, Kennedy, Stephen, Subramoney, Vishak, Briggs, Brittany, Fawzi, Wafaie W, Consortium, members of the GWG Pooling Project |
| المصدر: |
American Journal of Clinical Nutrition; Dec2022, Vol. 116 Issue 6, p1864-1876, 13p, 4 Charts, 4 Graphs |
| مصطلحات موضوعية: |
WEIGHT gain in pregnancy, RELATIVE medical risk, MIDDLE-income countries, META-analysis, CONFIDENCE intervals, SYSTEMATIC reviews, IRON, PREGNANT women, IRON in the body, DIETARY supplements, TREATMENT effectiveness, LOW-income countries, DESCRIPTIVE statistics, PRENATAL care, MICRONUTRIENTS, FOLIC acid, LIPIDS |
| مستخلص: |
Background Gestational weight gain (GWG) below or above the Institute of Medicine (IOM) recommendations has been associated with adverse perinatal outcomes. Few studies have examined the effect of prenatal nutrient supplementations on GWG in low- and middle-income countries (LMICs). Objectives We aimed to investigate the effects of multiple micronutrient supplements (MMSs) and small-quantity lipid-based nutrient supplements (LNSs) on GWG in LMICs. Methods A 2-stage meta-analysis of individual participant data was conducted to examine the effects of MMSs (45,507 women from 14 trials) and small-quantity LNSs (6237 women from 4 trials) on GWG compared with iron and folic acid supplements only. Percentage adequacy of GWG and total weight gain at delivery were calculated according to the IOM 2009 guidelines. Binary outcomes included severely inadequate (percentage adequacy <70%), inadequate (<90%), and excessive (>125%) GWG. Results from individual trials were pooled using fixed-effects inverse-variance models. Heterogeneity was examined using I 2, stratified analysis, and meta-regression. Results MMSs resulted in a greater percentage adequacy of GWG [weighted mean difference (WMD): 0.86%; 95% CI: 0.28%, 1.44%; P < 0.01] and higher GWG at delivery (WMD: 209 g; 95% CI: 139, 280 g; P < 0.01) than among those in the control arm. Women who received MMSs had a 2.9% reduced risk of severely inadequate GWG (RR: 0.971; 95% CI: 0.956, 0.987; P < 0.01). No association was found between small-quantity LNSs and GWG percentage adequacy (WMD: 1.51%; 95% CI: −0.38%, 3.40%; P = 0.21). Neither MMSs nor small-quantity LNSs were associated with excessive GWG. Conclusions Maternal MMSs were associated with greater GWG percentage adequacy and total GWG at delivery than was iron and folic acid only. This finding is consistent with previous results on birth outcomes and will inform policy development and local recommendations of switching routine prenatal iron and folic acid supplements to MMSs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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