التفاصيل البيبلوغرافية
| العنوان: |
Breast cancer risk in papilloma patients: Osteopontin splice variants indicate prognosis. |
| المؤلفون: |
Ziółkowski, Piotr, Woźniak, Marta, Mansour, Ahmad, An, Yu, Weber, Georg F. |
| المصدر: |
Breast Cancer Research; 9/29/2022, Vol. 24 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: |
PROTEINS, PAPILLOMA, MONOCLONAL antibodies, PROGNOSIS, RESEARCH funding, BREAST tumors |
| مستخلص: |
Background: Papillomas of the breast pose challenges for treatment decisions as their risk for transformation to breast cancer is low but not negligible. To spare low-risk patients the burden of substantial treatment side effects, prognostic indicators are needed for cancerous progression. The secreted metastasis mediator Osteopontin (OPN) is a marker for breast cancer aggressiveness, and its variants are prognosticators for transformation in diverse premalignant breast lesions. Here, we test whether the presence of OPN-c or OPN-exon-4 in papillomatous lesions may reflect progression risk.Methods: By immunohistochemistry, we analyze OPN-c and OPN-exon-4 in papillomas from 114 women as well as correlations between staining and progression. In departure from prior spliced OPN biomarker publications, we utilize novel monoclonal antibodies.Results: Fewer than 5% of OPN-c pathology score 0-1 (intensity) versus almost 18% of score 2-3 experienced cancer in follow-up. Nine of 12 women, who progressed, had pathology scores of 2-3 for OPN-c intensity at the time of initial diagnosis, and none had a score of 0. When developing a combined risk score from intensity plus percent positivity for OPN-c, the progression risk for patients with low score was 3.2%, for intermediate score was 5.7%, and for high score was 18.8%. Papillomas in patients, who were later diagnosed with cancer in the contralateral breast, displayed stronger staining positivity than non-progressors.Conclusion: OPN splice variant immunohistochemistry on biopsies of breast papillomas will allow counseling of the patients on their risk to develop breast cancer at a later time. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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