التفاصيل البيبلوغرافية
| العنوان: |
Visuomotor performance at high altitude in COPD patients. Randomized placebo-controlled trial of acetazolamide. |
| المؤلفون: |
Scheiwiller, P. M., Furian, M., Buergin, A., Mayer, L. C., Schneider, S. R., Mademilov, M., Lichtblau, M., Muralt, L., Sheraliev, U., Sooronbaev, T. M., Ulrich, S., Bloch, K. E. |
| المصدر: |
Frontiers in Physiology; 9/8/2022, Vol. 13, p1-11, 11p |
| مصطلحات موضوعية: |
VISUOMOTOR coordination, ACETAZOLAMIDE, CHRONIC obstructive pulmonary disease, ALTITUDES, MICE (Computers) |
| مستخلص: |
Introduction: We evaluated whether exposure to high altitude impairs visuomotor learning in lowlanders with chronic obstructive pulmonary disease (COPD) and whether this can be prevented by acetazolamide treatment. Methods: 45 patients with COPD, living <800 m, FEV1 ≥40 to <80%predicted, were randomized to acetazolamide (375 mg/d) or placebo, administered 24h before and during a 2-day stay in a clinic at 3100 m. Visuomotor performance was evaluated with a validated, computer-assisted test (Motor-Task-Manager) at 760 m above sea level (baseline, before starting the study drug), within 4h after arrival at 3100 m and in the morning after one night at 3100 m. Main outcome was the directional error (DE) of cursor movements controlled by the participant via mouse on a computer screen during a target tracking task. Effects of high altitude and acetazolamide on DE during an adaptation phase, immediate recall and post-sleep recall were evaluated by regression analyses. www.ClinicalTrials.gov NCT03165890. Results: In 22 patients receiving placebo, DE at 3100 m increased during adaptation by mean 2.5°, 95%CI 2.2° to 2.7° (p < 0.001), during immediate recall by 5.3°, 4.6° to 6.1° (p < 0.001), and post-sleep recall by 5.8°, 5.0 to 6.7° (p < 0.001), vs. corresponding values at 760 m. In 23 participants receiving acetazolamide, corresponding DE were reduced by −0.3° (−0.6° to 0.1°, p = 0.120), −2.7° (−3.7° to −1.6°, p < 0.001) and −3.1° (−4.3° to −2.0°, p < 0.001), compared to placebo at 3100 m. Conclusion: Lowlanders with COPD travelling to 3100 m experienced altitude-induced impairments in immediate and post-sleep recall of a visuomotor task. Preventive acetazolamide treatment mitigated these undesirable effects. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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