التفاصيل البيبلوغرافية
| العنوان: |
Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation. |
| المؤلفون: |
Liu, Wangta, Hsu, Yin-Yin, Tang, Jen-Yang, Cheng, Yuan-Bin, Chuang, Ya-Ting, Jeng, Jiiang-Huei, Yen, Chia-Hung, Chang, Hsueh-Wei |
| المصدر: |
Antioxidants; Sep2022, Vol. 11 Issue 9, p1813-1813, 19p |
| مصطلحات موضوعية: |
CANCER cell proliferation, ORAL cancer, CANCER cell culture, PLANT extracts, CANCER cells, ORAL mucosa, DNA damage, CASPASES |
| مستخلص: |
Data regarding the effects of crude extract of Commelina plants in oral cancer treatment are scarce. This present study aimed to assess the proliferation-modulating effects of the Commelina sp. (MECO) methanol extract on oral cancer cells in culture, Ca9-22, and CAL 27. MECO suppressed viability to a greater extent in oral cancer cells than in normal cells. MECO also induced more annexin V, apoptosis, and caspase signaling for caspases 3/8/9 in oral cancer cells. The preferential antiproliferation and apoptosis were associated with cellular and mitochondrial oxidative stress in oral cancer cells. Moreover, MECO also preferentially induced DNA damage in oral cancer cells by elevating γH2AX and 8-hydroxyl-2′-deoxyguanosine. The oxidative stress scavengers N-acetylcysteine or MitoTEMPO reverted these preferential antiproliferation mechanisms. It can be concluded that MECO is a natural product with preferential antiproliferation effects and exhibits an oxidative stress-associated mechanism in oral cancer cells. [ABSTRACT FROM AUTHOR] |
|
Copyright of Antioxidants is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder