التفاصيل البيبلوغرافية
| العنوان: |
Upregulation of Mineralocorticoid Receptor Contributes to Development of Salt-Sensitive Hypertension after Ischemia–Reperfusion Injury in Rats. |
| المؤلفون: |
Matsumoto, Takumi, Doi, Shigehiro, Nakashima, Ayumu, Ike, Takeshi, Sasaki, Kensuke, Masaki, Takao |
| المصدر: |
International Journal of Molecular Sciences; Jul2022, Vol. 23 Issue 14, p7831-7831, 19p |
| مصطلحات موضوعية: |
MINERALOCORTICOID receptors, REPERFUSION injury, RENAL artery, RENIN-angiotensin system, ACUTE kidney failure, SODIUM channels |
| مستخلص: |
The ischemia–reperfusion injury (IRI) of rat kidneys is used as a model of acute kidney injury. Salt-sensitive hypertension occurs in rats after IRI, and the distal nephrons play important roles in the development of this condition. We investigated the role of the mineralocorticoid receptor (MR) in the progression of IRI-induced salt-sensitive hypertension in rats. Fourteen days after right-side nephrectomy, IRI was induced by clamping the left renal artery, with sham surgery performed as a control. IRI rats were provided with normal water or water with 1.0% NaCl (IRI/NaCl), or they were implanted with an osmotic mini-pump to infuse vehicle or aldosterone (IRI/Aldo). Esaxerenone, a non-steroidal MR blocker (MRB), was administered to IRI/NaCl and IRI/Aldo rats for 6 weeks. MR expression increased by day 7 post-IRI. Blood pressure and urinary protein excretion increased in IRI/NaCl and IRI/Aldo rats over the 6-week period, but these effects were negated by MRB administration. The MRB attenuated the expression of the gamma-epithelial sodium channel (ENaC) and renal damage. The ENaC inhibitor, amiloride, ameliorated hypertension and renal damage in IRI/NaCl and IRI/Aldo rats. Our findings thus showed that MR upregulation may play a pivotal role in ENaC-mediated sodium uptake in rats after IRI, resulting in the development of salt-sensitive hypertension in response to salt overload or the activation of the renin–angiotensin–aldosterone system. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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