التفاصيل البيبلوغرافية
| العنوان: |
Maternal Body Mass Index, Early-Pregnancy Metabolite Profile, and Birthweight. |
| المؤلفون: |
Wahab, Rama J., Jaddoe, Vincent W. V., Voerman, Ellis, Ruijter, George J. G., Felix, Janine F., Marchioro, Linda, Uhl, Olaf, Shokry, Engy, Koletzko, Berthold, Gaillard, Romy |
| المصدر: |
Journal of Clinical Endocrinology & Metabolism; Jan2022, Vol. 107 Issue 1, pe315-e327, 13p |
| مصطلحات موضوعية: |
BODY mass index, BIRTH weight, FREE fatty acids, PREGNANCY, KREBS cycle, GESTATIONAL age |
| مستخلص: |
Context: Maternal prepregnancy body mass index (BMI) has a strong influence on gestational metabolism, but detailed metabolic alterations are unknown. Objective: First, to examine the associations of maternal prepregnancy BMI with maternal early-pregnancy metabolite alterations. Second, to identify an early-pregnancy metabolite profile associated with birthweight in women with a higher prepregnancy BMI that improved prediction of birthweight compared to glucose and lipid concentrations. Design, Setting, and Participants: Prepregnancy BMI was obtained in a subgroup of 682 Dutch pregnant women from the Generation R prospective cohort study. Main Outcome Measures: Maternal nonfasting targeted amino acids, nonesterified fatty acid, phospholipid, and carnitine concentrations measured in blood serum at mean gestational age of 12.8 weeks. Birthweight was obtained from medical records. Results: A higher prepregnancy BMI was associated with 72 altered amino acids, nonesterified fatty acid, phospholipid and carnitine concentrations, and 6 metabolite ratios reflecting Krebs cycle, inflammatory, oxidative stress, and lipid metabolic processes (P-values < 0.05). Using penalized regression models, a metabolite profile was selected including 15 metabolites and 4 metabolite ratios based on its association with birthweight in addition to prepregnancy BMI. The adjusted R2 of birthweight was 6.1% for prepregnancy BMI alone, 6.2% after addition of glucose and lipid concentrations, and 12.9% after addition of the metabolite profile. Conclusions: A higher maternal prepregnancy BMI was associated with altered maternal early-pregnancy amino acids, nonesterified fatty acids, phospholipids, and carnitines. Using these metabolites, we identified a maternal metabolite profile that improved prediction of birthweight in women with a higher prepregnancy BMI compared to glucose and lipid concentrations. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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