التفاصيل البيبلوغرافية
| العنوان: |
Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics. |
| المؤلفون: |
Salim, Elnaz, Ramachandran, Vasudevan, Ansari, Neda, Ismail, Patimah, Mohamed, Mohd Hazmi, Mohamad, Nur Afiqah, Inche Mat, Liyana Najwa |
| المصدر: |
Genetics Research; 5/16/2022, p1-7, 7p |
| مصطلحات موضوعية: |
ESSENTIAL hypertension, GENETIC polymorphisms, PREPROENDOTHELIN, DIASTOLIC blood pressure, MALAYS (Asian people), APOLIPOPROTEIN E4, SYSTOLIC blood pressure |
| مستخلص: |
Objectives. Endothelin-1 (ET-1), the most potent endogenous vasoconstrictor, generated by enzymatic cleavage catalyzed by an endothelin-converting enzyme (ECE), plays a significant role in the regulation of hypertension. Methods. This study investigates the effect of endothelin-1 (Lys198Asn/rs5370) and ECE (rs212526 C/T) gene polymorphisms with essential hypertension (EH) among Malay ethnics. To determine the association of gene polymorphism, 177 hypertensives and controls (196) were genotyped using Taqman method. Results. A significant difference was observed in ET-1 rs5370 and ECE rs212526 gene polymorphisms between EH and control subjects (P < 0.001). A significantly high body mass index (BMI), waist-to-hip ratio, fasting plasma glucose, hemoglobin A1c, systolic and diastolic blood pressure, and lipid profiles were observed among the EH patients when compared to controls (P < 0.05). Moreover, T allele (rs5370) carriers in males have a high risk for EH. There was no significant association between gender in ECE C/T polymorphisms (P > 0.05). Conclusion. Based on our result, it is evident that the T allele of ET-1 rs5370 polymorphism and C allele of ECE rs212526 have a significant genetic risk factor in EH among Malay subjects, and BMI and age are associated with hypertension. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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