التفاصيل البيبلوغرافية
| العنوان: |
Influence of Strongyloides stercoralis Coinfection on the Presentation, Pathogenesis, and Outcome of Tuberculous Meningitis. |
| المؤلفون: |
Donovan, Joseph, Tram, Trinh Thi Bich, Phu, Nguyen Hoan, Hiep, Nguyen Thi Thu, Van, Vu Thi Thu, Mui, Dang Thi Hong, Ny, Nguyen Thi Han, Nghia, Ho Dang Trung, Hanh, Nguyen Ho Hong, Tan, Le Van, Thuong, Nguyen Thuy Thuong, Thwaites, Guy E |
| المصدر: |
Journal of Infectious Diseases; May2022, Vol. 225 Issue 9, p1653-1662, 10p |
| مصطلحات موضوعية: |
TUBERCULOUS meningitis, TUMOR necrosis factors, SYMPTOMS, MIXED infections, MYCOBACTERIUM tuberculosis, HELMINTHIASIS, NEMATODES, INFLAMMATION, RESEARCH funding, DISEASE complications |
| مستخلص: |
Background: Helminth infections may modulate the inflammatory response to Mycobacterium tuberculosis and influence disease presentation and outcome. Strongyloides stercoralis is common among populations with high tuberculosis prevalence. Our aim was to determine whether S. stercoralis coinfection influenced clinical presentation, cerebrospinal fluid (CSF) inflammation, and outcome from tuberculous meningitis (TBM).Methods: From June 2017 to December 2019, 668 Vietnamese adults with TBM, enrolled in the ACT HIV or LAST ACT trials (NCT03092817 and NCT03100786), underwent pretreatment S. stercoralis testing by serology, stool microscopy, and/or stool polymerase chain reaction. Comparisons of pretreatment TBM severity, CSF inflammation (including cytokines), and 3-month clinical end points were performed in groups with or without active S. stercoralis infection.Results: Overall, 9.4% participants (63 of 668) tested positive for S. stercoralis. Active S. stercoralis infection was significantly associated with reduced pretreatment CSF neutrophil counts (median [interquartile range], 3/μL [0-25/μL] vs 14 /μL [1-83/μL]; P = .04), and with reduced CSF interferon ɣ, interleukin 2, and tumor necrosis factor α concentrations (11.4 vs 56.0 pg/mL [P = .01], 33.1 vs 54.5 pg/mL [P = .03], and 4.5 vs 11.9 pg/mL [P = .02], respectively), compared with uninfected participants. Neurological complications by 3 months were significantly reduced in participants with active S. stercoralis infection compared with uninfected participants (3.8% [1 of 26] vs 30.0% [33 of 110], respectively; P = .01).Conclusions: S. stercoralis coinfection may modulate the intracerebral inflammatory response to M. tuberculosis and improve TBM clinical outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
