التفاصيل البيبلوغرافية
| العنوان: |
Effectiveness of crizotinib versus entrectinib in -positive non-small-cell lung cancer using clinical and real-world data. |
| المؤلفون: |
Tremblay, Gabriel, Groff, Michael, Iadeluca, Laura, Daniele, Patrick, Wilner, Keith, Wiltshire, Robin, Bartolome, Lauren, Usari, Tiziana, Cappelleri, Joseph C, Camidge, D Ross |
| المصدر: |
Future Oncology; Jun2022, Vol. 18 Issue 17, p2063-2074, 12p |
| مصطلحات موضوعية: |
LUNG cancer, PROTEINS, HETEROCYCLIC compounds, PROTEIN kinase inhibitors, LUNG tumors, PROTEIN-tyrosine kinases, RESEARCH funding, BENZAMIDE |
| مستخلص: |
Aims: To compare clinical trial results for crizotinib and entrectinib in ROS1-positive non-small-cell lung cancer and compare clinical trial data and real-world outcomes for crizotinib. Patients & methods: We analyzed four phase I-II studies using a simulated treatment comparison (STC). A STC of clinical trial versus real-world evidence compared crizotinib clinical data to real-world outcomes. Results: Adjusted STC found nonsignificant trends favoring crizotinib over entrectinib: objective response rate, risk ratio = 1.04 (95% CI: 0.85-1.28); median duration of response, mean difference = 16.11 months (95% CI: -1.57- 33.69); median progression-free survival, mean difference = 3.99 months (95% CI: -6.27-14.25); 12-month overall survival, risk ratio = 1.01 (95% CI: 0.90-1.12). Nonsignificant differences were observed between the trial end point values and the real-world evidence for crizotinib. Conclusions: Crizotinib and entrectinib have comparable efficacy in ROS1-positive non-small-cell lung cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
