التفاصيل البيبلوغرافية
| العنوان: |
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials. |
| المؤلفون: |
Keir, Stephen T., Dolan, M. Eileen, Pegg, Anthony E., Lawless, Amy, Moschel, Robert C., Bigner, Darell D., Friedman, Henry S., Keir, S T, Dolan, M E, Pegg, A E, Lawless, A, Moschel, R C, Bigner, D D, Friedman, H S |
| المصدر: |
Cancer Chemotherapy & Pharmacology; Jun2000, Vol. 45 Issue 6, p437-440, 4p |
| مصطلحات موضوعية: |
CANCER treatment, TUMORS, CANCER patients, CANCER, REGRESSION analysis, TRANSPLANTATION of organs, tissues, etc. |
| مستخلص: |
Purpose: To evaluate the role of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine (O6-BG) in the treatment of both Mer+ and Mer- tumors.Methods: The effect of pretreatment with O6-BG on the activity of BCNU against Mer- human central nervous tumor xenografts D-54 MG and D-245 MG was evaluated in athymic nude mice.Results: BCNU (1.0 LD10; dose lethal to 10% of treated animals) produced growth delays of 8.9 days and 7.5 days and tumor regressions in six of ten and one of nine animals against D-54 MG, which was derived from a human malignant glioma xenograft. Dose reduction of BCNU to 0.38 LD10 eliminated antitumor activity. The combination of BCNU (0.38 LD10) plus O6-BG produced growth delays of 8.8 days and 7.9 days, with tumor regressions in four of ten and two of nine animals, respectively. BCNU (1.0 LD10) produced a growth delay of 49.8 days and ten of ten tumor regressions against D-245 MG, which was derived from a glioblastoma multiforme. BCNU (0.38 LD10) produced a growth delay of 19.4 days, with nine of ten tumor regressions. The combination of BCNU (0.38 LD10) plus O6-BG produced a growth delay of 65.7 days and seven of eight tumor regressions.Conclusion: These results suggest that the combination of BCNU plus O6-BG may be a rational intervention for both Mer+ as well as Mer- tumors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
