التفاصيل البيبلوغرافية
| العنوان: |
Prenatal supplementation with multiple micronutrient supplements or medium-quantity lipid-based nutrient supplements has limited effects on child growth up to 24 months in rural Niger: a secondary analysis of a cluster randomized trial. |
| المؤلفون: |
Bliznashka, Lilia, Sudfeld, Christopher R, Garba, Souna, Guindo, Ousmane, Soumana, Issaka, Adehossi, Irène, Langendorf, Céline, Grais, Rebecca F, Isanaka, Sheila |
| المصدر: |
American Journal of Clinical Nutrition; Mar2022, Vol. 115 Issue 3, p738-748, 11p, 2 Diagrams, 3 Charts, 3 Graphs |
| مصطلحات موضوعية: |
HUMAN growth, CONFIDENCE intervals, CHILD development, RURAL conditions, DIETARY supplements, RANDOMIZED controlled trials, BLIND experiment, DESCRIPTIVE statistics, PRENATAL care, MICRONUTRIENTS, DATA analysis software, LIPIDS, SECONDARY analysis |
| مصطلحات جغرافية: |
NIGERIA |
| مستخلص: |
Background Prenatal multiple micronutrient supplementation (MMS) and lipid-based nutrient supplementation (LNS) can improve birth outcomes relative to iron-folic acid supplementation (IFA); however, effects on child postnatal growth remain unclear. Objectives The aim was to compare the effect of prenatal MMS, medium-quantity LNS (MQ-LNS), and IFA on child growth up to 2 y of age. Methods We conducted a cluster randomized controlled trial of prenatal nutritional supplementation in Madarounfa, Niger. Villages were randomly assigned for pregnant women to receive IFA (17 villages, 1105 women), MMS (18 villages, 1083 women) or MQ-LNS (18 villages, 1144 women). Pregnant women received nutritional supplements weekly until delivery, and children were followed up monthly from 6-8 wk to 24 mo of age. We assessed the effect of prenatal MMS and MQ-LNS compared with IFA and the effect of prenatal MMS compared with MQ-LNS on child length-for-age z scores (LAZ), weight-for-age z scores (WAZ), and weight-for-length z scores (WLZ) at 24 mo of age using generalized linear models. In secondary analyses, we used mixed-effects models to assess the trajectories of anthropometric z scores longitudinally from 6–8 wk to 24 mo. Results Compared with IFA, MMS and MQ-LNS had no effect on child LAZ, WAZ, or WLZ at 24 mo of age (P > 0.05). Children in the MQ-LNS arm had significantly higher mid-upper arm circumference at 24 mo than children in the MMS arm: mean difference 0.50 cm (95% CI 0.10, 0.91 cm). WAZ and WLZ trajectories were more negative in the MQ-LNS arm compared with IFA and MMS, with lower z scores from 14 to 20 mo of age. However, WAZ and WLZ trajectories converged after 20 mo of age, and there were no differences by 24 mo of age. Conclusions Prenatal MMS and MQ-LNS had limited effect on anthropometric measures of child growth up to 24 mo of age as compared with IFA in rural Niger. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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