التفاصيل البيبلوغرافية
| العنوان: |
Menstrual Toxic Shock Syndrome: A French Nationwide Multicenter Retrospective Study. |
| المؤلفون: |
Contou, Damien, Colin, Gwenhaël, Travert, Brendan, Jochmans, Sébastien, Conrad, Marie, Lascarrou, Jean-Baptiste, Painvin, Benoit, Ferré, Alexis, Schnell, David, Combe, Beatrice La, Coudroy, Rémi, Ehrmann, Stephan, Rambaud, Jérôme, Wiedemann, Arnaud, Asfar, Pierre, Kalfon, Pierre, Guérot, Emmanuel, Préau, Sébastien, Argaud, Laurent, Daviet, Florence |
| المصدر: |
Clinical Infectious Diseases; 1/15/2022, Vol. 74 Issue 2, p246-253, 8p |
| مصطلحات موضوعية: |
ANTIBIOTICS, RESEARCH, INTENSIVE care units, VASOCONSTRICTORS, MENSTRUATION disorders, IMMUNOGLOBULINS, CRITICALLY ill, RESEARCH methodology, PATIENTS, RETROSPECTIVE studies, MEDICAL cooperation, METHICILLIN-resistant staphylococcus aureus, CULTURES (Biology), DESCRIPTIVE statistics, TOXIC shock syndrome, TRACHEA intubation, SYMPTOMS |
| مصطلحات جغرافية: |
FRANCE |
| الشركة/الكيان: |
CENTERS for Disease Control & Prevention (U.S.) |
| مستخلص: |
Background Studies describing the clinical features and short-term prognosis of patients admitted to the intensive care unit (ICU) for menstrual toxic shock syndrome (m-TSS) are lacking. Methods This was a multicenter retrospective cohort study of patients with a clinical diagnosis of m-TSS admitted between 1 January 2005 and 31 December 2020 in 43 French pediatric (n = 7) or adult (n = 36) ICUs. The aim of the study was to describe the clinical features and short-term prognosis, as well as to assess the 2011 Centers for Disease and Control (CDC) diagnostic criteria, in critically ill patients with m-TSS. Results In total, 102 patients with m-TSS (median age, 18 years; interquartile range, 16–24 years) were admitted to 1 of the participating ICUs. All blood cultures (n = 102) were sterile. Methicillin-sensitive Staphylococcus aureus grew from 92 of 96 vaginal samples. Screening for superantigenic toxin gene sequences was performed for 76 of the 92 vaginal samples positive for S. aureus (83%), and toxic shock syndrome toxin 1 was isolated from 66 strains (87%). At ICU admission, no patient met the 2011 CDC criteria for confirmed m-TSS, and only 53 (52%) fulfilled the criteria for probable m-TSS. Eighty-one patients (79%) were treated with antitoxin antibiotic therapy, and 8 (8%) received intravenous immunoglobulins. Eighty-six (84%) patients required vasopressors, and 21 (21%) tracheal intubation. No patient required limb amputation or died in the ICU. Conclusions In this large multicenter series of patients included in ICUs for m-TSS, none died or required limb amputation. The CDC criteria should not be used for the clinical diagnosis of m-TSS at ICU admission. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
