التفاصيل البيبلوغرافية
| العنوان: |
New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic. |
| المؤلفون: |
Salmi, Heli, Heinonen, Santtu, Hästbacka, Johanna, Lääperi, Mitja, Rautiainen, Paula, Miettinen, Päivi J., Vapalahti, Olli, Hepojoki, Jussi, Knip, Mikael |
| المصدر: |
Archives of Disease in Childhood; Feb2022, Vol. 107 Issue 2, p180-185, 13p |
| مصطلحات موضوعية: |
TYPE 1 diabetes, COVID-19 pandemic, DIABETES in children, DELAYED diagnosis, PEDIATRIC intensive care, PERIPROSTHETIC fractures |
| مستخلص: |
Background: Viral infections may trigger type 1 diabetes (T1D), and recent reports suggest an increased incidence of paediatric T1D and/or diabetic ketoacidosis (DKA) during the COVID-19 pandemic.Objective: To study whether the number of children admitted to the paediatric intensive care unit (PICU) for DKA due to new-onset T1D increased during the COVID-19 pandemic, and whether SARS-CoV-2 infection plays a role.Methods: This retrospective cohort study comprises two datasets: (1) children admitted to PICU due to new-onset T1D and (2) children diagnosed with new-onset T1D and registered to the Finnish Pediatric Diabetes Registry in the Helsinki University Hospital from 1 April to 31 October in 2016-2020. We compared the incidence, number and characteristics of children with newly diagnosed T1D between the prepandemic and pandemic periods.Results: The number of children admitted to PICU due to new-onset T1D increased from an average of 6.25 admissions in 2016-2019 to 20 admissions in 2020 (incidence rate ratio [IRR] 3.24 [95% CI 1.80 to 5.83]; p=0.0001). On average, 57.75 children were registered to the FPDR in 2016-2019, as compared with 84 in 2020 (IRR 1.45; 95% CI 1.13 to 1.86; p=0.004). 33 of the children diagnosed in 2020 were analysed for SARS-CoV-2 antibodies, and all were negative.Conclusions: More children with T1D had severe DKA at diagnosis during the pandemic. This was not a consequence of SARS-CoV-2 infection. Instead, it probably stems from delays in diagnosis following changes in parental behaviour and healthcare accessibility. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
