التفاصيل البيبلوغرافية
| العنوان: |
Coronary Vasculature and Myocardial Structure in HIV: Physiologic Insights From the Renin-Angiotensin-Aldosterone System. |
| المؤلفون: |
Srinivasa, Suman, Thomas, Teressa S., Feldpausch, Meghan N., Adler, Gail K., Grinspoon, Steven K. |
| المصدر: |
Journal of Clinical Endocrinology & Metabolism; Dec2021, Vol. 106 Issue 12, p3398-3412, 15p |
| مصطلحات موضوعية: |
RENIN-angiotensin system, HIV, MYOCARDIAL injury |
| مستخلص: |
The landscape of HIV medicine dramatically changed with the advent of contemporary antiretroviral therapies, which has allowed persons with HIV (PWH) to achieve good virologic control, essentially eliminating HIV-related complications and increasing life expectancy. As PWH are living longer, noncommunicable diseases, such as cardiovascular disease (CVD), have become a leading cause of morbidity and mortality in PWH with rates that are 50% to 100% higher than in well-matched persons without HIV. In this review, we focus on disease of the coronary microvasculature and myocardium in HIV. We highlight a key hormonal system important to cardiovascular endocrinology, the renin-angiotensin-aldosterone system (RAAS), as a potential mediator of inflammatory driven-vascular and myocardial injury and consider RAAS blockade as a physiologically targeted strategy to reduce CVD in HIV. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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