التفاصيل البيبلوغرافية
| العنوان: |
Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2. |
| المؤلفون: |
Wertheim, Joel O., Hostager, Reilly, Ryu, Diane, Merkel, Kevin, Angedakin, Samuel, Arandjelovic, Mimi, Ayimisin, Emmanuel Ayuk, Babweteera, Fred, Bessone, Mattia, Brun-Jeffery, Kathryn J., Dieguez, Paula, Eckardt, Winnie, Fruth, Barbara, Herbinger, Ilka, Jones, Sorrel, Kuehl, Hjalmar, Langergraber, Kevin E., Lee, Kevin, Madinda, Nadege F., Metzger, Sonja |
| المصدر: |
Molecular Biology & Evolution; Jul2021, Vol. 38 Issue 7, p2818-2830, 13p |
| مصطلحات موضوعية: |
VIRAL genetics, COMMUNICABLE diseases, PATHOGENIC microorganisms, PATHOGENIC viruses, HUMAN herpesvirus 1 |
| مستخلص: |
Viruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and cross-species transmission. We report the discovery of novel herpes simplexviruses during a large-scale screening of fecal samples from wild gorillas, bonobos, and chimpanzees. Phylogenetic analysis indicates that, contrary to expectation, simplexviruses from these African apes are all more closely related to HSV-2 than to HSV-1. Molecular clock-based hypothesis testing suggests the divergence between HSV-1 and the African great ape simplexviruses likely represents a codivergence event between humans and gorillas. The simplexviruses infecting African great apes subsequently experienced multiple cross-species transmission events over the past 3 My, the most recent of which occurred between humans and bonobos around 1 Ma. These findings revise our understanding of the origins of human herpes simplexviruses and suggest that HSV-2 is one of the earliest zoonotic pathogens. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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