التفاصيل البيبلوغرافية
| العنوان: |
Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience. |
| المؤلفون: |
Meacci, Elisa, Nachira, Dania, Zanfrini, Edoardo, Evangelista, Jessica, Triumbari, Elizabeth Katherine Anna, Congedo, Maria Teresa, Petracca Ciavarella, Leonardo, Chiappetta, Marco, Vita, Maria Letizia, Schinzari, Giovanni, Rossi, Ernesto, Tortora, Giampaolo, Lucchi, Marco, Ambrogi, Marcello, Calabrò, Fabrizia, Petrella, Francesco, Spaggiari, Lorenzo, Mammana, Marco, Lloret Madrid, Andrea, Rea, Federico |
| المصدر: |
Cancers; Jul2021, Vol. 13 Issue 13, p3258-3258, 1p |
| مصطلحات موضوعية: |
RENAL cell carcinoma, RESEARCH, ACQUISITION of data methodology, METASTASIS, LUNG tumors, MEDICAL cooperation, RETROSPECTIVE studies, SURGERY, PATIENTS, SEX distribution, CANCER patients, MEDICAL records, SURVIVAL analysis (Biometry), KARNOFSKY Performance Status, LACTATE dehydrogenase, LUNG surgery |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Simple Summary: This multicentric paper aimed at evaluating the role of pulmonary metastasectomy in patients affected by metastatic renal cell carcinoma. The impact of pulmonary metastasectomy was analysed with respect to long-term survival and disease-free survival in a wide population of patients affected by pulmonary metastases from renal cell carcinoma. The prognostic value of factors affecting survival, disease-free interval and disease-free survival was evaluated. Our results aid clinicians in identifying those patients affected by pulmonary metastases from renal cell carcinoma who are more likely to benefit from pulmonary metastasectomy. In this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free survival (DFS) after PM and before lung recurrence. Medical records of 210 patients who underwent PM from RCC in 4 Italian Thoracic Centres, from January 2000 to September 2019, were collected and analysed. All patients underwent RCC resection before lung surgery. The main RCC histology was clear cells (188, 89.5%). The 5- and 10-year OS from the first lung operation were 60% and 34%, respectively. LM synchronous with RCC (p = 0.01) and (Karnofsky Performance Status Scale) KPSS < 80% (p < 0.001) negatively influenced OS. Five- and 10-year DFI were 54% and 28%, respectively. The main factors negatively influencing DFI were: male gender (p = 0.039), KPSS < 80% (p = 0.009) and lactate dehydrogenase > 1.5 times 140 U/L (p = 0.001). Five- and 10-year disease-free survival were 54% and 28%, respectively; multiple LM (p = 0.036), KPSS < 80% (p = 0.001) and histology of RCC other than clear cells negatively influenced disease-free survival. Conclusions: patients with KPSS > 80%, single metachronous LM with a long DFI from RCC diagnosis, and clear cell histology, benefit from pulmonary metastasectomy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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