التفاصيل البيبلوغرافية
| العنوان: |
Effect of Methanol Extract of Baobab (Adansonia digitata L.) Fruit Pulp on NG-Nitro-l-Arginine Methyl Ester (l-NAME) Induced Hypertension in Rats. |
| المؤلفون: |
Liman, Abubakar Alhaji, Salihu, Aliyu, Onyike, Elewechi |
| المصدر: |
High Blood Pressure & Cardiovascular Prevention; May2021, Vol. 28 Issue 3, p291-300, 10p |
| مصطلحات موضوعية: |
ANTIHYPERTENSIVE agents, HYPERTENSION, BLOOD pressure, BIOMARKERS, C-reactive protein, INTERLEUKINS, METHANOL, ANIMAL experimentation, ARGININE, RATS, OXIDATIVE stress, LACTATE dehydrogenase, PLANT extracts, RAMIPRIL, NITRIC oxide, HEMODYNAMICS, HIGH density lipoproteins, ANGIOTENSIN converting enzyme |
| مستخلص: |
Introduction: Most available drugs used for management of hypertension have presented a plethora of challenges which genuinely called for development of therapies from natural sources. Aim: This study investigated the effect of methanol extract of Adansonia digitata fruit (MEADF) pulp on NG-nitro-l-arginine methyl ester (l-NAME) induced hypertension in rats. Methods: Fourty eight (48) wistar rats divided into six (6) groups (eight rats each) were employed. The induction of hypertension was achieved using l-NAME (40mg//kg body weight) by oral gavages. The induced rats were treated with MEADF pulp (200 and 400 mg/kg body weight) and Ramipril (10 mg/kg) and the remaining three groups serve as control. Serum haemodynamic and biochemical modifiable parameters were determined using standard assay procedures Results: Administration of MEADF to the rats exerted a dose-dependent lowering effect on the elevated systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate towards the normal physiological threshold. At 400 mg/kg of MEADF, there was significant (p < 0.05) reduction in serum lipid profile and biomarkers associated with endothelial dysfunction [angiotensin converting enzyme (ACE) activity], inflammation (C-reactive protein and interleukin-1β), oxidative stress (malondialdehyde) and cardiac injury (creatine kinase-MB and lactate dehydrogenase activities). However, serum concentrations of nitric oxide, high density lipoprotein cholesterol, total bilirubin and albumin were not significantly (p < 0.05) different from those found in normal control group. Conclusion: This study therefore demonstrates that MEADF possesses an in vivo ACE inhibitory activity, hypotensive potential and the ability to avert further degeneration of biochemical and physiological upsets associated with l-NAME induced hypertension. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
