التفاصيل البيبلوغرافية
| العنوان: |
Survey of newborn direct antiglobulin testing practice in United States and Canadian transfusion services. |
| المؤلفون: |
Crowe, Elizabeth P., Goel, Ruchika, Andrews, Jennifer, Meyer, Erin K., Wong, Trisha E., Sloan, Steven R., Delaney, Meghan, Lieberman, Lani, Cushing, Melissa M. |
| المصدر: |
Transfusion; Apr2021, Vol. 61 Issue 4, p1080-1092, 13p |
| مصطلحات موضوعية: |
COOMBS' test, CHILDREN'S hospitals, ERYTHROCYTES, ERYTHROBLASTOSIS fetalis, UMBILICAL cord |
| مصطلحات جغرافية: |
UNITED States, CANADA |
| مستخلص: |
Background: We hypothesized that variability in practice exists for newborn immunohematology testing due to lack of consensus guidelines. We report the results of a survey assessing that variability at hospitals in the United States and Canada.Study Design and Methods: An AABB Pediatric Subsection working party developed and validated a survey of newborn immunohematology testing practice. The survey was sent electronically to transfusion service leadership at teaching institutions.Results: The response rate was 67% (61/91); 56 surveys meeting inclusion criteria were analyzed. Approximately 90% (50/56) were from birth hospitals and 16.1% (9/56) were from pediatric hospitals. Newborn immunohematology testing is ordered as a panel by 66.0% (33/50) of birth hospitals. ABO group and DAT is mandated before discharge in 14/56 (25.0%) and 13/56 (23.2%), respectively. About 76.8% (43/56) selectively perform a DAT according to blood blank or clinical parameters. The most common DAT practices include anti-IgG only testing by 73.2% (41/56) and use of umbilical cord specimen type by 67.9% (38/56). A positive DAT is a critical value for 26.8% (15/56) and followed with eluate testing when a maternal antibody screen is positive for 48.2% (27/56). In the setting of a non-ABO maternal red cell antibody, 55.4% (31/56), phenotype neonatal red cells when the DAT is positive. Group O RBC are transfused irrespective of the DAT result for 82.1%, (46/56).Conclusion: There is variability in newborn immunohematology testing and transfusion practice and potential overutilization of the DAT. Evidence-based consensus guidelines should be developed to standardize practice and to improve safety. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
