التفاصيل البيبلوغرافية
| العنوان: |
Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum. |
| المؤلفون: |
Reiss, Timo, Theis, Hannah I., Gonzalez‐Delgado, Andres, Vega‐Rodriguez, Joel, Zipfel, Peter F., Skerka, Christine, Pradel, Gabriele |
| المصدر: |
European Journal of Immunology; Feb2021, Vol. 51 Issue 2, p490-493, 4p |
| مصطلحات موضوعية: |
PLASMODIUM, PLASMODIUM falciparum, PLASMINOGEN, TISSUE plasminogen activator, ECULIZUMAB |
| مستخلص: |
Keywords: Complement system; Immune evasion; Malaria; plasminogen; Plasmodium falciparum EN Complement system Immune evasion Malaria plasminogen Plasmodium falciparum 490 493 4 02/08/21 20210201 NES 210201 We show that the intraerythrocytic stages of the malaria parasite I Plasmodium falciparum i bind plasminogen and mediate its conversion into plasmin to inactivate parasite-bound C3b. GLO:BVO/01feb21:eji4918-gra-0001.jpg PHOTO (COLOR): . gl Abbreviations pAb polyclonal Ab Plg plasminogen Plm plasmin TCC terminal complement complex The tropical disease malaria claims more than 400,000 victims every year. Mediated by the urokinase-type and tissue-type plasminogen activators uPA and tPA, Plg can be converted into the serine protease plasmin (Plm), which is involved in fibrin degradation but can also process complement factors such as C3 and C5 [7,8]. (B) SZs were incubated with Plg-depleted plasma ( Plg) with/without Plg and/or tPA for 1 h and subjected to ELISA, using mAb TCC (technical triplicate; mean ± SD; Plg set to 1). [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
