التفاصيل البيبلوغرافية
| العنوان: |
Long Noncoding RNA FOXP4-AS1 Predicts Unfavourable Prognosis and Regulates Proliferation and Invasion in Hepatocellular Carcinoma. |
| المؤلفون: |
Liang, Jingchen, Wang, Duo, Qiu, Guanhua, Zhu, Xiaoqi, Liu, Junjie, Li, Hang, Guo, Pingping |
| المصدر: |
BioMed Research International; 2/1/2021, p1-12, 12p |
| مصطلحات موضوعية: |
RISK of metastasis, RNA analysis, CELL proliferation, CANCER patients, CANCER invasiveness, CELL lines, COMPARATIVE studies, GENE expression, HEPATOCELLULAR carcinoma, ONCOGENES, POLYMERASE chain reaction, TUMOR markers, GENE expression profiling, CELL migration inhibition, CHRONIC hepatitis C, PATHOLOGIC neovascularization, IN vitro studies, DISEASE risk factors |
| مستخلص: |
Background. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer that has a high level of morbidity and mortality. Long noncoding RNA (lncRNA) is a novel regulatory factor of tumour proliferation, apoptosis, and metastasis. Our previous studies indicated that lncRNA FOXP4-AS1 is a functional oncogene in HCC; thus, this study is aimed at further evaluating the clinical and biological function of FOXP4-AS1 in HCC. Material and Methods. First, we detected the expression of FOXP4-AS1 in HCC tissues and paracarcinoma normal tissues by qRT-PCR. Second, the prognostic effects of FOXP4-AS1 in patients with HCC were analysed in a training group and a verification group. Subsequently, to investigate the biological effects of FOXP4-AS1 on HCC cells, downexpression tests were further conducted. Results. The expression of FOXP4-AS1 was higher in HCC tissues than adjacent nontumourous tissues, whereas the low expression of FOXP4-AS1 was correlated with optimistic treatment outcomes, which suggested that FOXP4-AS1 may be an independent prognostic biomarker for HCC. Moreover, the downregulation of FOXP4-AS1 significantly reduced the cell proliferation and clonal abilities and inhibited the invasion, migration, and angiogenesis of hepatoma cells (P < 0.05). Conclusion. These results revealed the clinical significance and biological function of FOXP4-AS1 in HCC development, which may provide a new direction for finding therapeutic targets and potential prognostic biomarkers of HCC. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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