التفاصيل البيبلوغرافية
| العنوان: |
STUDY AND ASSESSMENTOF ACCUMULATION AND TOXICITY OF CALCIUM OXIDE NANOPARTICLES INGESTED BY ORALADMINISTRATION. |
| المؤلفون: |
Zaytseva, N. V., Zemlyanova, M. A., Stepankov, M. S., Ignatova, A. M. |
| المصدر: |
Proceedings of the International Multidisciplinary Scientific GeoConference SGEM; 2020, p125-131, 7p |
| مصطلحات موضوعية: |
LIME (Minerals), ALANINE aminotransferase, ASPARTATE aminotransferase, ANIMAL mortality, LACTATE dehydrogenase, DYSTROPHY, UREA |
| مستخلص: |
he researchand evaluationof calcium oxide nanoparticles’(CaO)accumulation and toxicity when ingested orallywere carried out.The results,obtained afterthe study of CaO nanopowder by scanning electron microscopymethod, demonstrate,that a large proportion of particles in its composition havea size of up to 100 nm, a rounded shape and a smooth surface, while the microparticles of the chemical analog have a cubic shape with a rough surface.According to the death rate,LD50 values were calculatedformale Wistar rats with single and multiple doses of CaOnanoparticles, amounting to 2000 and 2900 mg/kg of body weight, respectively.From the recorded datathe cumulative coefficient was 1.45, which indicates the pronounced cumulative properties of the nanomaterial.Due to the absence of animal deaths in the comparison groups, the cumulation coefficient for CaOmicroparticles has not been established.When ingestedorally, CaOnanoparticles accumulate in the liver at concentrations that exceed this ratewhen exposed to a microdispersed analog by 1.25 times, causing hyaline-drop dystrophy of hepatocytes, while only single eosinophils in the portal tracts were observed in animalsof the comparison group. Pathomorphological changes in the liver of experiment and comparison animal groups are accompanied by changes in blood biochemical parameters.An increase in the levels of alanine aminotransferase, aspartate aminotransferase, bilirubin total, gamma-glutamyltransferase, lactate dehydrogenase and a decrease in urea levels weredetected. At the same time, the toxic effect of CaOnanoparticles is more pronounced, what is manifested by the elevated levels of aspartate aminotransferase and bilirubin, which are 1.58 and 2.67 times higher than these indicators at ingestion of microparticles.The revealed features of bioaccumulation, pathomorphological changes and changes in the biochemical status during of CaOnanoparticles when ingested orallyindicate a greater toxicity of the studied nanomaterial in comparison with the microdispersed analog. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
