التفاصيل البيبلوغرافية
| العنوان: |
S-Adenosylmethionine Inhibits Cell Growth and Migration of Triple Negative Breast Cancer Cells through Upregulating MiRNA-34c and MiRNA-449a. |
| المؤلفون: |
Coppola, Alessandra, Ilisso, Concetta Paola, Stellavato, Antonietta, Schiraldi, Chiara, Caraglia, Michele, Mosca, Laura, Cacciapuoti, Giovanna, Porcelli, Marina |
| المصدر: |
International Journal of Molecular Sciences; Jan2021, Vol. 22 Issue 1, p286, 1p |
| مصطلحات موضوعية: |
TRIPLE-negative breast cancer, CELL migration, CELL growth, ADENOSYLMETHIONINE, CANCER cells, CELL migration inhibition |
| مستخلص: |
Triple-negative breast cancer (TNBC) is one of the most common malignancies worldwide and shows maximum invasiveness and a high risk of metastasis. Recently, many natural compounds have been highlighted as a valuable source of new and less toxic drugs to enhance breast cancer therapy. Among them, S-adenosyl-L-methionine (AdoMet) has emerged as a promising anti-cancer agent. MicroRNA (miRNA or miR)-based gene therapy provides an interesting antitumor approach to integrated cancer therapy. In this study, we evaluated AdoMet-induced modulation of miRNA-34c and miRNA-449a expression in MDA-MB-231 and MDA-MB-468 TNBC cells. We demonstrated that AdoMet upregulates miR-34c and miR-449a expression in both cell lines. We found that the combination of AdoMet with miR-34c or miR-449a mimic strongly potentiated the pro-apoptotic effect of the sulfonium compound by a caspase-dependent mechanism. For the first time, by video time-lapse microscopy, we showed that AdoMet inhibited the in vitro migration of MDA-MB-231 and MDA-MB-468 cells and that the combination with miR-34c or miR-449a mimic strengthened the effect of the sulfonium compound through the modulation of β-catenin and Small Mother Against Decapentaplegic (SMAD) signaling pathways. Our results furnished the first evidence that AdoMet exerts its antitumor effects in TNBC cells through upregulating the expression of miR-34c and miR-449a. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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