التفاصيل البيبلوغرافية
| العنوان: |
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. |
| المؤلفون: |
Scholes, Harry M., Cryar, Adam, Kerr, Fiona, Sutherland, David, Gethings, Lee A., Vissers, Johannes P. C., Lees, Jonathan G., Orengo, Christine A., Partridge, Linda, Thalassinos, Konstantinos |
| المصدر: |
Scientific Reports; 10/28/2020, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
BRAIN proteins, ALZHEIMER'S disease, MOLECULAR pathology, PROTEIN-protein interactions, DISEASE progression, PROTEOMICS, DROSOPHILA melanogaster, ANIMAL models in research |
| مستخلص: |
Alzheimer's disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Understanding the molecular pathology of AD during disease progression may identify new ways to reduce neuronal damage. Here, we present a longitudinal study tracking dynamic proteomic alterations in the brains of an inducible Drosophila melanogaster model of AD expressing the Arctic mutant Aβ42 gene. We identified 3093 proteins from flies that were induced to express Aβ42 and age-matched healthy controls using label-free quantitative ion-mobility data independent analysis mass spectrometry. Of these, 228 proteins were significantly altered by Aβ42 accumulation and were enriched for AD-associated processes. Network analyses further revealed that these proteins have distinct hub and bottleneck properties in the brain protein interaction network, suggesting that several may have significant effects on brain function. Our unbiased analysis provides useful insights into the key processes governing the progression of amyloid toxicity and forms a basis for further functional analyses in model organisms and translation to mammalian systems. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder