التفاصيل البيبلوغرافية
| العنوان: |
Primary pancreatic lymphoma: Clinical presentation, diagnosis, treatment, and outcome. |
| المؤلفون: |
Facchinelli, Davide, Sina, Sokol, Boninsegna, Enrico, Borin, Alex, Tisi, Maria C., Piazza, Francesco, Scapinello, Greta, Maiolo, Elena, Hohaus, Stefan, Zamò, Alberto, Merli, Michele, Stefani, Piero M., Mellone, Federica, Basso, Marco, Sartori, Roberto, Rusconi, Chiara, Parisi, Alice, Manfrin, Erminia, Krampera, Mauro, Ruggeri, Marco |
| المصدر: |
European Journal of Haematology; Oct2020, Vol. 105 Issue 4, p468-475, 8p |
| مصطلحات موضوعية: |
LYMPHOMAS, DIFFUSE large B-cell lymphomas, LACTATE dehydrogenase, CENTRAL nervous system, SYMPTOMS, DIAGNOSIS |
| مستخلص: |
Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of malignant lymphomas, which lacks well‐defined diagnostic and therapeutic protocols. Objectives: To describe PPL clinical, diagnostic and histological characteristics, together with therapy and outcome, in a relatively large series of patients. Methods: The study includes 39 PPL patients, aged ≥15 years, observed from January 2005 to December 2018, in 8 Italian Institutions. Results: The main symptoms were abdominal pain (58%) and jaundice (47%). Lactate dehydrogenase serum levels were elevated in 43% of patients. Histological specimens were mostly obtained by percutaneous (41%) or endoscopic (36%) biopsy, with diffuse large B‐cell lymphoma being the most frequent (69%) histological diagnosis. Chemotherapy was administered alone in 65% of patients, with radiotherapy in 17%, or after surgery in 9%. The 2‐year overall survival (OS) was 62%, the 2‐year progression‐free survival (PFS) 44%. Debulking surgery (with or without chemotherapy) was associated with a significant worse OS. Three (9.4%) of 32 high‐grade patients experienced a central nervous system (CNS) relapse. Conclusions: PPL is rare, often high‐grade, with symptoms and localization similar to other pancreatic malignancies. Biopsy should be the preferred diagnostic method. High‐grade PPL should undergo CNS prophylaxis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
