التفاصيل البيبلوغرافية
| العنوان: |
Thiethylperazine-induced parkinsonism:in vivodemonstration of dopamine D2 receptors blockade. |
| المؤلفون: |
Briani, C., Cagnin, A., Chierichetti, F., Tiberio, M., Battistin, L., Pizzolato, G. |
| المصدر: |
European Journal of Neurology; Oct2004, Vol. 11 Issue 10, p709-710, 2p |
| مصطلحات موضوعية: |
PARKINSON'S disease, VERTIGO, DOPAMINE, EXTRAPYRAMIDAL disorders, CENTRAL nervous system diseases, VESTIBULAR apparatus diseases, NEUROLOGIC manifestations of general diseases, NEUROLOGICAL disorders |
| مستخلص: |
Thiethylperazine (Torecan®) is a piperazine phenothiazine employed to relieve vertigo. Its use may be associated with extrapyramidal side effects (dystonia, akathisia, tardive dyskinesia) (), but parkinsonism has rarely been described. We describe a woman who, 1 month after the onset of thiethylperazine treatment, developed parkinsonism that disappeared 2 months after withdrawal of the drug. However, cerebral single-photon emission computed tomography (SPECT) with the dopamine (DA) D2 receptors ligand123I-iodobenzamide (123I-IBZM) revealed a persistent reduced DA D2 receptors activity (by 45%) in the basal ganglia (BG), which may be clinically not effective. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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