التفاصيل البيبلوغرافية
| العنوان: |
Normalized grip strength is a sensitive outcome measure through all stages of Duchenne muscular dystrophy. |
| المؤلفون: |
Hogrel, Jean-Yves, Decostre, Valérie, Ledoux, Isabelle, de Antonio, Marie, Niks, Erik H., de Groot, Imelda, Straub, Volker, Muntoni, Francesco, Ricotti, Valeria, Voit, Thomas, Seferian, Andreea, Gidaro, Teresa, Servais, Laurent |
| المصدر: |
Journal of Neurology; Jul2020, Vol. 267 Issue 7, p2022-2028, 7p, 1 Color Photograph, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
GRIP strength, DUCHENNE muscular dystrophy, ABSOLUTE value, NATURAL history |
| مستخلص: |
Objective: The main aim was to explore the changes in hand-grip strength in patients with Duchenne muscular dystrophy (DMD) aged 5–29 years. Secondary aims were to test the effect of mutation, ambulatory status and glucocorticoid use on grip strength and its changes over time and to compute the number of subjects needed for a clinical trial to stabilize grip strength. Methods: The analysis was performed on data collected during five international natural history studies on a cohort of DMD patients. Two hundred and two patients with genetically proven DMD were pooled from five different natural history studies. Excepting 13 patients with only one visit, the mean duration of follow-up was 2.2 ± 1.6 years. A total of 977 measurement points were collected. Grip strength was measured on the dominant side with a high precision dynamometer. The analysis was performed using absolute values and normalized values expressed in percentage of predicted values for age. Results: For absolute values, grip strength typically increased in ambulatory boys and decreased in non-ambulatory patients. However, when normalized, grip strength was already reduced at age 5 years and thereafter continued to fall away from normal values. The weaker the patients, the less strength they are prone to lose over again. Interpretation: Grip strength constitutes a sensitive and continuous outcome measure that can be used across all stages of DMD. Its measurement is easy to standardized, can be used in ambulatory and non-ambulatory patients and does not present any floor or ceiling effect. It is thus attractive as an outcome measure in therapeutic trials. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Neurology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
