التفاصيل البيبلوغرافية
| العنوان: |
Tolerance and effect of sodium thiosulfate in calcific tendinitis of the rotator cuff. |
| المؤلفون: |
Darrieurtort-Laffite, C., Bertrand-Vasseur, A., Garraud, T., Planche, L., Le Goff, B. |
| المصدر: |
Clinical Rheumatology; Feb2020, Vol. 39 Issue 2, p561-569, 9p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
ROTATOR cuff, TENDINITIS, CLINICAL trial registries, THIOSULFATES, SHOULDER pain, CALCINOSIS |
| مستخلص: |
Background: Calcific tendinitis of the rotator cuff is one of the most common causes of shoulder pain. Ultrasound-guided percutaneous lavage of calcific tendinopathy is performed when conservative treatments have failed. Sodium thiosulfate (STS) has recently been used with success in the treatment of tumoral calcinosis. The goal of this phase II study was to assess the tolerance and the feasibility of STS lavage of calcific tendinopathy. Methods: We included patient with type hard calcifications. Patients were treated with puncture and lavage followed by injection of STS in the calcification. VAS pain at rest and during activities, ultrasound, and X-ray were evaluated at 1 week and 1 and 3 months. Results: Seventeen patients were included. Baseline VAS at rest and during daily activities was a mean 40.2 ± 25.9 and 65.5 ± 21.6 respectively. All patients underwent the entire procedure with no adverse event. Calcium backflow could be obtained in 15 patients (88.2%). Five patients (30%) had more than 50% decrease of their calcific deposit size at 1 month and 8 (47%) patients at 3 months. VAS pain during activities and at rest decreased significantly at 3 months (p = 0.0004; p = 0.001). Efficacy would be demonstrated if 60% of the patients had more than 50% decrease size of their calcification Conclusion: Overall, STS was well tolerated with no side effect occurring during the procedure and the follow-up. However, no significant effect on calcium disappearance could be demonstrated compared with what is expected without STS. New studies using larger volume and repeated injections of STS are now needed. Clinical trial registration number: NCT02538939 Key Points • Lavage of calcific tendinopathy of the rotator cuff with sodium thiosulfate is feasible • No adverse events have been observed after or in the 3 months after the procedure • We could not demonstrate that sodium thiosulfate increases the chance of calcium disappearance • New studies using larger volume and repeated injections of STS are needed to further explore the interest of sodium thiosulfate in the treatment of calcific tendinopathy [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
