التفاصيل البيبلوغرافية
| العنوان: |
Anti-Biofilm Effects of Synthetic Antimicrobial Peptides Against Drug-Resistant Pseudomonas aeruginosa and Staphylococcus aureus Planktonic Cells and Biofilm. |
| المؤلفون: |
Park, Seong-Cheol, Lee, Min-Young, Kim, Jin-Young, Kim, Hyeonseok, Jung, Myunghwan, Shin, Min-Kyoung, Lee, Woo-Kon, Cheong, Gang-Won, Lee, Jung Ro, Jang, Mi-Kyeong, Tamamura, Hirokazu |
| المصدر: |
Molecules; Dec2019, Vol. 24 Issue 24, p4560, 1p, 2 Diagrams, 1 Chart, 4 Graphs |
| مصطلحات موضوعية: |
PEPTIDOMIMETICS, STAPHYLOCOCCUS aureus, PEPTIDE antibiotics, PSEUDOMONAS aeruginosa, CELL membranes, MICROCYSTIS aeruginosa, MULTIDRUG resistance, ANTIBIOTICS |
| مستخلص: |
Biofilm-associated infections are difficult to manage or treat as biofilms or biofilm-embedded bacteria are difficult to eradicate. Antimicrobial peptides have gained increasing attention as a possible alternative to conventional drugs to combat drug-resistant microorganisms because they inhibit the growth of planktonic bacteria by disrupting the cytoplasmic membrane. The current study investigated the effects of synthetic peptides (PS1-2, PS1-5, and PS1-6) and conventional antibiotics on the growth, biofilm formation, and biofilm reduction of drug-resistant Pseudomonas aeruginosa and Staphylococcus aureus. The effects of PS1-2, PS1-5, and PS1-6 were also tested in vivo using a mouse model. All peptides inhibited planktonic cell growth and biofilm formation in a dose-dependent manner. They also reduced preformed biofilm masses by removing the carbohydrates, extracellular DNA, and lipids that comprised extracellular polymeric substances (EPSs) but did not affect proteins. In vivo, PS1-2 showed the greatest efficacy against preformed biofilms with no cytotoxicity. Our findings indicate that the PS1-2 peptide has potential as a next-generation therapeutic drug to overcome multidrug resistance and to regulate inflammatory response in biofilm-associated infections. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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