التفاصيل البيبلوغرافية
| العنوان: |
Influence of acute reduction of blood viscosity on endothelial function. |
| المؤلفون: |
Gnasso, Agostino, Cacia, Michele, Cutruzzolà, Antonio, Minieri, Marilena, Carallo, Claudio, Cortese, Claudio, Irace, Concetta |
| المصدر: |
Clinical Hemorheology & Microcirculation; 2019, Vol. 72 Issue 3, p239-245, 7p |
| مصطلحات موضوعية: |
BLOOD viscosity, FUNCTIONS of bounded variation, BLOOD plasma, BLOOD flow, VASODILATION |
| مستخلص: |
BACKGROUND: The relationship between blood viscosity (BV) and endothelial function is rather complex. An increase in BV causes an increase in blood flow resistance, with negative hemodynamic effects; on the other hand, a moderate increase in BV causes an increase in wall stress shear (WSS), and consequent beneficial effects. As a matter of fact, the effect of changes in BV on endothelial function is not yet clear. OBJECTIVES: Aim of the present study was to evaluate in-vivo the effects of the acute reduction in BV on endothelial function, in healthy male subjects. METHODS: Fourteen healthy male blood donors were studied before and 48 hours after blood donation. Blood and plasma viscosity were measured at 37C° with a cone-plate viscometer. Endothelial function was evaluated through flow mediated vasodilation (FMD). RESULTS: Blood viscosity was reduced after blood donation (BV225 (cP) 4.53±0.59 vs.4.18±0.31, p < 0.05). FMD 50 s after cuff deflation was unchanged: 6.23±3.84 vs. 6.62±4.81, p = NS. The vasodilation, however, lasted longer and the area under the curve of FMD was significantly increased: 8.74±8.77 vs.16.14±8.65, p < 0.005. CONCLUSIONS: The present results demonstrate that the acute reduction of BV prolongs vasodilation, without affecting the amount of vasodilatation, possibly as adaptive reaction allowing more time for oxygen release. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
