التفاصيل البيبلوغرافية
| العنوان: |
Continuous plasma resin perfusion for detoxification of methotrexate. |
| المؤلفون: |
Greil, J, Wyss, P A, Ludwig, K, Bonakdar, S, Scharf, J, Beck, J D, Ruder, H |
| المصدر: |
European Journal of Pediatrics; 1997, Vol. 156 Issue 8, p533-536, 4p |
| مستخلص: |
Unlabelled: Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred.Conclusion: The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
