التفاصيل البيبلوغرافية
| العنوان: |
Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome. |
| المؤلفون: |
Picard, Marion A L, Vicoso, Beatriz, Roquis, David, Bulla, Ingo, Augusto, Ronaldo C, Arancibia, Nathalie, Grunau, Christoph, Boissier, Jérôme, Cosseau, Céline |
| المصدر: |
Genome Biology & Evolution; Jul2019, Vol. 11 Issue 7, p1909-1922, 14p |
| مصطلحات موضوعية: |
SCHISTOSOMA mansoni, DRUG dosage, CHROMATIN, CHROMOSOMES, WAGES, X chromosome |
| مستخلص: |
Differentiated sex chromosomes are accompanied by a difference in gene dose between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked genes can lead to expression imbalance, or gene dosage can be compensated by epigenetic mechanisms and results into expression level equalization. Schistosoma mansoni has been previously described as a ZW species (i.e. female heterogamety, in opposition to XY male heterogametic species) with a partial dosage compensation, but underlying mechanisms are still unexplored. Here, we combine transcriptomic (RNA-Seq) and epigenetic data (ChIP-Seq against H3K4me3, H3K27me3, and H4K20me1 histone marks) in free larval cercariae and intravertebrate parasitic stages. For the first time, we describe differences in dosage compensation status in ZW females, depending on the parasitic status: free cercariae display global dosage compensation, whereas intravertebrate stages show a partial dosage compensation. We also highlight regional differences of gene expression along the Z chromosome in cercariae, but not in the intravertebrate stages. Finally, we feature a consistent permissive chromatin landscape of the Z chromosome in both sexes and stages. We argue that dosage compensation in schistosomes is characterized by chromatin remodeling mechanisms in the Z-specific region. [ABSTRACT FROM AUTHOR] |
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