التفاصيل البيبلوغرافية
| العنوان: |
The association between gender and HIV viral suppression on third-line therapy in Zambia: a retrospective cohort study. |
| المؤلفون: |
Andronescu, Liana, Zulu, Paul M, Jackson, Sarah S, Hachaambwa, Lottie, Claassen, Cassidy W, Stafford, Kristen A |
| المصدر: |
International Journal of STD & AIDS; Apr2019, Vol. 30 Issue 5, p453-459, 7p, 4 Charts |
| مصطلحات موضوعية: |
COHORT analysis, GENDER, VIRAL load, HIV, HIV-positive persons, HIV infection epidemiology, DRUG resistance in microorganisms, HIV infections, SEX distribution, HIGHLY active antiretroviral therapy, TREATMENT effectiveness, RETROSPECTIVE studies, ANTI-HIV agents, CD4 lymphocyte count, IMPACT of Event Scale |
| مصطلحات جغرافية: |
ZAMBIA, LUSAKA (Zambia) |
| مستخلص: |
Patient's gender may impact pharmacokinetics and play a role in viral suppression. Existing literature has focused on treatment-naïve patients and produced inconclusive results, often implicating differences in adherence as the driver of gender-based outcome differences. The present analysis assessed whether viral suppression on third-line HIV treatment among a closely followed population differs by gender. A retrospective cohort study of patients on third-line HIV treatment was initiated at the HIV Advanced Treatment Centre in Lusaka, Zambia between January 2012 and December 2015. The association between gender and viral suppression was assessed using log binomial regression adjusted for core drug, number of drug mutations, and baseline viral load. Of the 80 included patients (56% female; median age: 40 years), 50 (62%) were virally suppressed at six months. After adjustment, females were less likely to be virologically suppressed at six months on third-line treatment compared to male HIV patients (relative risk 0.82, 95% confidence interval: 0.56, 1.20). Our data suggest that women were less likely to be suppressed following six months of third-line therapy compared to men; however, the difference was not statistically significant. Larger studies are needed to determine whether women are at increased risk of viral failure on third-line therapy compared to men. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
