التفاصيل البيبلوغرافية
| العنوان: |
Long‐term Persistence with Mirabegron versus Solifenacin in Women with Overactive Bladder: Prospective, Randomized Trial. |
| المؤلفون: |
KINJO, Manami, SEKIGUCHI, Yuki, YOSHIMURA, Yasukuni, NUTAHARA, Kikuo |
| المصدر: |
LUTS; May2018, Vol. 10 Issue 2, p148-152, 5p |
| مصطلحات موضوعية: |
OVERACTIVE bladder, ADRENERGIC receptors, MUSCARINIC antagonists, WOMEN patients, PERSISTENCE |
| مستخلص: |
Objectives: To compare persistence with medication and the reasons for discontinuation of mirabegron or solifenacin therapy up to12 months in women with overactive bladder (OAB). Methods: Female OAB patients who presented to women's urology clinics were enrolled in a prospective, randomized, two‐arm study. Patients were randomized to receive mirabegron at 25–50 mg (n = 76) or solifenacin at 2.5–5 mg (n = 72). The persistence rate and the reasons for discontinuation were investigated up to 12 months. Results: The 12‐month persistence rate was 12.2% in the mirabegron group versus 20.1% in the solifenacin group and there were no significant differences of the persistence rates during the study (n.s). Patients discontinued treatment because of lack of efficacy (21.6%), spontaneous improvement (18.2%), and side‐effects (17.6%), while 19.6% were lost to follow up. Discontinuation due to side‐effects was significantly more frequent in the solifenacin group than the mirabegron group (27.3 vs. 7.9%, P < 0.05). In contrast, discontinuation due to lack of efficacy was significantly more frequent in the mirabegron group than the solifenacin group (36.8 vs. 5.6%, P < 0.05). Conclusions: This study demonstrated low persistence rates over 12 months for both mirabegron and solifenacin, although the reasons for discontinuation were somewhat different. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
