التفاصيل البيبلوغرافية
| العنوان: |
Distinct Roles of Endothelial Dysfunction and Inflammation in Intracranial Atherosclerotic Stroke. |
| المؤلفون: |
Chung, Jong-Won, Oh, Mi Jeong, Cho, Yeon Hee, Moon, Gyeong Joon, Kim, Gyeong-Moon, Chung, Chin-Sang, Lee, Kwang Ho, Bang, Oh Young |
| المصدر: |
European Neurology; Mar2017, Vol. 77 Issue 3/4, p211-219, 9p, 5 Charts, 1 Graph |
| مصطلحات موضوعية: |
ENDOTHELIUM diseases, INFLAMMATION, STROKE |
| مستخلص: |
Background/Aims: The aim of the study was to evaluate the differential roles of endothelial dysfunction and inflammation in intracranial atherosclerotic stroke (ICAS). Methods: We prospectively recruited 262 patients with acute cerebral infarcts caused by ICAS and 75 individuals with no history of stroke as controls. Markers of endothelial dysfunction (asymmetric dimethylarginine, ADMA) and inflammation (lipoprotein-associated phospholipase A2, Lp-PLA2 ) were measured. Acute ischemic lesions were measured in terms of their size, composition, and patterns. Subclinical microangiopathy (degree of leukoaraiosis) and macroangiopathy (presence/ number of asymptomatic stenoses) were graded in each patient. Results: Compared to normal controls, serum levels of ADMA (0.69 ± 0.14 vs. 0.47 ± 0.10, p < 0.001) and Lp-PLA2 (138.1 ± 116.8 vs. 19.0 ± 58.0, p < 0.001) were elevated in patients with ICAS. A high ADMA serum level was associated with greater prevalence of preclinical microangiopathy and macroangiopathy. Contrastingly, an elevated serum Lp-PLA2 level was associated with larger ischemic lesions, a greater number of lesions, and a larger cortical pattern. Conclusions: Endothelial dysfunction and inflammation have distinct effects in ICAS patents; endothelial dysfunction is associated with the underlying micro- and macro-atherosclerotic burden, whereas inflammation is associated with acute infarct volume and pattern. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Neurology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
