التفاصيل البيبلوغرافية
| العنوان: |
Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease. |
| المؤلفون: |
Huan Olsen, Rasmus, Rørholm Pedersen, Lene, Snoer, Martin, Emil Christensen, Thomas, Ali Ghotbi, Adam, Hasbak, Philip, Kjaer, Andreas, Haugaard, Steen B., Prescott, Eva, Olsen, Rasmus Huan, Pedersen, Lene Rørholm, Christensen, Thomas Emil, Ghotbi, Adam Ali |
| المصدر: |
Cardiovascular Ultrasound; 6/7/2016, p1-12, 12p |
| مصطلحات موضوعية: |
CORONARY circulation, OVERWEIGHT persons, POSITRON emission tomography, CORONARY disease, STANDARD deviations, PATIENTS, CORONARY heart disease complications, CORONARY heart disease surgery, OBESITY complications, BLOOD flow measurement, COMPARATIVE studies, CORONARY arteries, DOPPLER echocardiography, HEMODYNAMICS, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, MYOCARDIAL revascularization, RESEARCH, RESEARCH evaluation, STATISTICAL sampling, PILOT projects, EVALUATION research, RANDOMIZED controlled trials, CORONARY angiography, PHYSIOLOGY |
| مستخلص: |
Background: Coronary flow velocity reserve (CFVR) measured by transthoracic Doppler echocardiography of the LAD is used to assess microvascular function but validation studies in clinical settings are lacking. We aimed to assess feasibility, reproducibility and agreement with myocardial flow reserve (MFR) measured by PET in overweight and obese patients.Methods: Participants with revascularized coronary artery disease were examined by CFVR. Subgroups were examined by repeated CFVR (reproducibility) or Rubidium-82-PET (agreement). To account for time variation, results were computed for scans performed within a week (1-week) and for all scans regardless of time gap (total) and to account for scar tissue for patients with and without previous myocardial infarction (MI).Results: Eighty-six patients with median BMI 30.9 (IQR 29.4-32.9) kg × m(-2) and CFVR 2.29 (1.90-2.63) were included. CFVR was feasible in 83 (97 %) using a contrast agent in 14 %. For reproducibility overall (n = 21) limits of agreement (LOA) were (-0.75;0.71), within-subjects coefficient of variation (CV) 11 %, and reliability 0.84. For reproducibility within 1-week (n = 13) LOA were (-0.33;0.25), within-subjects CV 5 %, and reliability 0.97. Agreement with MFR of the LAD territory (n = 35) was without significant bias and overall LOA were (-1.40;1.46). Agreement was best for examinations performed within 1-week of participants without MI of the LAD-territory (n = 12); LOA = (-0.68;0.88).Conclusions: CFVR was highly feasible with a good reproducibility on par with other contemporary measures applied in cardiology. Agreement with MFR was acceptable, though discrepancy related to prior MI has to be considered. CFVR of LAD is a valid tool in overweight and obese patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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