التفاصيل البيبلوغرافية
| العنوان: |
Validation of T2* in-line analysis for tissue iron quantification at 1.5 T. |
| المؤلفون: |
Alam, Mohammed H., Taigang He, Auger, Dominique, Smith, Gillian C., Drivas, Peter, Wage, Rick, Izgi, Cemil, Symmonds, Karen, Greiser, Andreas, Spottiswoode, Bruce S., Anderson, Lisa, Firmin, David, Pennell, Dudley J. |
| المصدر: |
Journal of Cardiovascular Magnetic Resonance (BioMed Central); 4/27/2016, Vol. 18, p1-7, 7p, 2 Color Photographs, 1 Chart, 3 Graphs |
| مصطلحات موضوعية: |
IRON analysis, HOSPITALS, BIOPSY, CONFIDENCE intervals, STATISTICAL correlation, LIVER, MAGNETIC resonance imaging, RESEARCH methodology, MYOCARDIUM, PROBABILITY theory, REGRESSION analysis, RESEARCH evaluation, RESEARCH funding, INTER-observer reliability, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, MANN Whitney U Test |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Background: There is a need for improved worldwide access to tissue iron quantification using T2* cardiovascular magnetic resonance (CMR). One route to facilitate this would be simple in-line T2* analysis widely available on MR scanners. We therefore compared our clinically validated and established T2* method at Royal Brompton Hospital (RBH T2*) against a novel work-in-progress (WIP) sequence with in-line T2* measurement from Siemens (WIP T2*). Methods: Healthy volunteers (n = 22) and patients with iron overload (n = 78) were recruited (53 males, median age 34 years). A 1.5 T study (Magnetom Avanto, Siemens) was performed on all subjects. The same mid-ventricular short axis cardiac slice and transaxial slice through the liver were used to acquire both RBH T2* images and WIP T2* maps for each participant. Cardiac white blood (WB) and black blood (BB) sequences were acquired. Intraobserver, interobserver and interstudy reproducibility were measured on the same data from a subset of 20 participants. Results: Liver T2* values ranged from 0.8 to 35.7 ms (median 5.1 ms) and cardiac T2* values from 6.0 to 52.3 ms (median 31 ms). The coefficient of variance (CoV) values for direct comparison of T2* values by RBH and WIP were 6.1-7.8 % across techniques. Accurate delineation of the septum was difficult on some WIP T2* maps due to artefacts. The inability to manually correct for noise by truncation of erroneous later echo times led to some overestimation of T2* using WIP T2* compared with the RBH T2*. Reproducibility CoV results for RBH T2* ranged from 1.5 to 5.7 % which were better than the reproducibility of WIP T2* values of 4.1-16.6 %. Conclusions: Iron estimation using the T2* CMR sequence in combination with Siemens' in-line data processing is generally satisfactory and may help facilitate global access to tissue iron assessment. The current automated T2* map technique is less good for tissue iron assessment with noisy data at low T2* values. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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