التفاصيل البيبلوغرافية
| العنوان: |
An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes. |
| المؤلفون: |
Bai, Ling, Yang, Howard H., Hu, Ying, Shukla, Anjali, Ha, Ngoc-Han, Doran, Anthony, Faraji, Farhoud, Goldberger, Natalie, Lee, Maxwell P., Keane, Thomas, Hunter, Kent W. |
| المصدر: |
PLoS Genetics; 4/13/2016, Vol. 12 Issue 4, p1-18, 18p |
| مصطلحات موضوعية: |
BREAST cancer diagnosis, DISEASE susceptibility, TUMORS, TUMOR growth, SINGLE nucleotide polymorphisms, GENE therapy |
| مستخلص: |
Metastasis remains the primary cause of patient morbidity and mortality in solid tumors and is due to the action of a large number of tumor-autonomous and non-autonomous factors. Here we report the results of a genome-wide integrated strategy to identify novel metastasis susceptibility candidate genes and molecular pathways in breast cancer metastasis. This analysis implicates a number of transcriptional regulators and suggests cell-mediated immunity is an important determinant. Moreover, the analysis identified novel or FDA-approved drugs as potentially useful for anti-metastatic therapy. Further explorations implementing this strategy may therefore provide a variety of information for clinical applications in the control and treatment of advanced neoplastic disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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