التفاصيل البيبلوغرافية
| العنوان: |
Prevalence of HLA-B27 in Moroccan healthy subjects and patients with ankylosing spondylitis and mapping construction of several factors influencing AS diagnosis by using multiple correspondence analysis. |
| المؤلفون: |
Akassou, Amal, Yacoubi, Hanae, Jamil, Afaf, Dakka, Nadia, Amzazi, Saaïd, Sadki, Khalid, Niamane, Redouane, Elhassani, Selma, Bakri, Youssef |
| المصدر: |
Rheumatology International; Nov2015, Vol. 35 Issue 11, p1889-1894, 6p, 3 Charts, 3 Graphs |
| مصطلحات موضوعية: |
HLA-B27 antigen, DISEASE prevalence, ANKYLOSING spondylitis, MOROCCANS, FAMILY history (Medicine), DIAGNOSIS, PATIENTS, DISEASES |
| مستخلص: |
The aim of the present study was to determine the prevalence of human leukocyte antigen HLA-B27 in Moroccan healthy controls and in patients with ankylosing spondylitis (AS), and to analyze the correlation between HLA-B27 and AS in Moroccan patients. The prevalence of HLA-B27 was determined by evaluating the number of HLA-B27-positive samples in 128 healthy subjects and in 53 patients diagnosed with AS according to the ESSG and AMOR criteria. HLA-B27 was determined by the polymerase chain reaction using sequence-specific primers. Multivariate analysis of our data (HLA-B27, age, sex, and family history) for AS and healthy controls was performed by multiple correspondence analysis (MCA). The frequency of HLA-B27 was significantly greater in AS patients (45.3 %) than in healthy controls (4.7 %) [ p < 0.0001, OR 16.8, and CI 95 % (5.83-51.03)]. In addition, HLA-B27 was more common in male patients than in female ones ( p < 0.05). 100 % of the AS patients reported a family history of AS, whereas only 20 % of the healthy controls reported a family history of AS. The graphical interpretation of MCA showed a significant relation between the presence of HLA-B27 and AS. This study strengthens the link between HLA-B27 and AS and represents a very valuable informative diagnostic tool, especially in regard to male patients who have a family history of AS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
