التفاصيل البيبلوغرافية
| العنوان: |
Ventilator-associated Pneumonia caused by commensal oropharyngeal a retrospective Analysis of a prospectively collected Database. |
| المؤلفون: |
Scholte, Johannes B. J., van der Velde, Johan I. M., Linssen, Catharina F. M., van Dessel, Helke A., Bergmans, Dennis C. J. J., Savelkoul, Paul H. M., Roekaerts, Paul M. H. J., van Mook, Walther N. K. A. |
| المصدر: |
BMC Pulmonary Medicine; Aug2015, Vol. 15 Issue 1, p1-15, 15p, 1 Diagram, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
PNEUMONIA, COMMENSALISM, BRONCHOALVEOLAR lavage, INTENSIVE care units, MECHANICAL ventilators |
| مستخلص: |
Background: The significance of commensal oropharyngeal flora (COF) as a potential cause of ventilator-associated pneumonia (VAP) is scarcely investigated and consequently unknown. Therefore, the aim of this study was to explore whether COF may cause VAP. Methods: Retrospective clinical, microbiological and radiographic analysis of all prospectively collected suspected VAP cases in which bronchoalveolar lavage fluid exclusively yielded ≥ 104 cfu/ml COF during a 9.5-year period. Characteristics of 899 recent intensive care unit (ICU) admissions were used as a reference population. Results: Out of the prospectively collected database containing 159 VAP cases, 23 patients were included. In these patients, VAP developed after a median of 8 days of mechanical ventilation. The patients faced a prolonged total ICU length of stay (35 days [P < .001]), hospital length of stay (45 days [P = .001]), and a trend to higher mortality (39 % vs. 26 %, [P = .158]; standardized mortality ratio 1.26 vs. 0.77, [P = .137]) compared to the reference population. After clinical, microbiological and radiographic analysis, COF was the most likely cause of respiratory deterioration in 15 patients (9.4 % of all VAP cases) and a possible cause in 2 patients. Conclusion: Commensal oropharyngeal flora appears to be a potential cause of VAP in limited numbers of ICU patients as is probably associated with an increased length of stay in both ICU and hospital. As COF-VAP develops late in the course of ICU admission, it is possibly associated with the immunocompromised status of ICU patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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