التفاصيل البيبلوغرافية
| العنوان: |
Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure. |
| المؤلفون: |
Natali D, Girerd B, Montani D, Soubrier F, Simonneau G, Humbert M, Sitbon O, Natali, Delphine, Girerd, Barbara, Montani, David, Soubrier, Florent, Simonneau, Gérald, Humbert, Marc, Sitbon, Olivier |
| المصدر: |
CHEST; Oct2011, Vol. 140 Issue 4, p1066-1068, 3p |
| مستخلص: |
We report a case of pulmonary arterial hypertension (PAH) occurring in a patient with Cowden syndrome with a mutation in the phosphatase and tensin (PTEN) tumor suppressor gene, in the context of exposure to the appetite suppressant dexfenfluramine. Anorexigen exposure is known to be a risk factor for PAH. However, the role of PTEN in cell function and the development of pulmonary vascular remodeling and histopathologic signs of PAH in mice with a Pten depletion in smooth muscle cells suggest that the association of PAH and Cowden syndrome may be relevant. In this case report, we hypothesize that PTEN mutations may be a predisposing factor for the development of PAH, with anorexigen exposure as a potential trigger. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
