التفاصيل البيبلوغرافية
| العنوان: |
Maximal oxygen uptake and severity of disease in lymphangioleiomyomatosis. |
| المؤلفون: |
Taveira-DaSilva AM, Stylianou MP, Hedin CJ, Kristof AS, Avila NA, Rabel A, Tavis WD, Moss J, Taveira-DaSilva, Angelo M, Stylianou, Mario P, Hedin, Carolyn J, Kristof, Arnold S, Avila, Nilo A, Rabel, Antoinette, Travis, William D, Moss, Joel |
| المصدر: |
American Journal of Respiratory & Critical Care Medicine; 2003, Vol. 168 Issue 12, p1427-1431, 5p |
| مستخلص: |
Lymphangioleiomyomatosis (LAM), a disease that occurs primarily in women, is characterized by cystic lung lesions causing respiratory failure, which may require lung transplantation. Lung diffusion (DLCO) and/or FEV1 are decreased, but frequently not in parallel with each other. Because cardiopulmonary exercise testing (CPET) provides information that is not obtainable from resting cardiopulmonary tests, we performed CPET in 217 LAM patients and correlated exercise data with clinical markers of severity, computed tomography scans, lung function, and histology. VO2max was decreased in 162 patients, of whom 28 did not reach anaerobic threshold; 29 had low oxygen uptake at anaerobic threshold, and 54 developed hypoxemia. Hypoxemia occurred even in patients with near normal DLCO and FEV1. VO2max decreased with an increasing score of histologic LAM severity and was correlated with computed tomography scans, the use of oxygen, and resting PaO2. DLCO and FEV1, however, were the only significant predictors of VO2max. We conclude that CPET uncovers the presence of exercise-induced hypoxemia and assists in grading the severity of disease and determining supplemental oxygen requirements in patients with LAM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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