التفاصيل البيبلوغرافية
| العنوان: |
Reliability of concentrations of organophosphate pesticide metabolites in serial urine specimens from pregnancy in the Generation R Study. |
| المؤلفون: |
Spaan, Suzanne, Pronk, Anjoeka, Koch, Holger M, Jusko, Todd A, Jaddoe, Vincent W V, Shaw, Pamela A, Tiemeier, Henning M, Hofman, Albert, Pierik, Frank H, Longnecker, Matthew P |
| المصدر: |
Journal of Exposure Science & Environmental Epidemiology; May/Jun2015, Vol. 25 Issue 3, p286-294, 9p |
| مصطلحات موضوعية: |
ORGANOPHOSPHORUS pesticides, URINE collection & preservation, PREGNANCY, METABOLITES, ADVERSE health care events, STATISTICAL correlation |
| مستخلص: |
The widespread use of organophosphate (OP) pesticides has resulted in ubiquitous exposure in humans, primarily through their diet. Exposure to OP pesticides may have adverse health effects, including neurobehavioral deficits in children. The optimal design of new studies requires data on the reliability of urinary measures of exposure. In the present study, urinary concentrations of six dialkyl phosphate (DAP) metabolites, the main urinary metabolites of OP pesticides, were determined in 120 pregnant women participating in the Generation R Study in Rotterdam. Intra-class correlation coefficients (ICCs) across serial urine specimens taken at <18, 18-25, and >25 weeks of pregnancy were determined to assess reliability. Geometric mean total DAP metabolite concentrations were 229 (GSD 2.2), 240 (GSD 2.1), and 224 (GSD 2.2) nmol/g creatinine across the three periods of gestation. Metabolite concentrations from the serial urine specimens in general correlated moderately. The ICCs for the six DAP metabolites ranged from 0.14 to 0.38 (0.30 for total DAPs), indicating weak to moderate reliability. Although the DAP metabolite levels observed in this study are slightly higher and slightly more correlated than in previous studies, the low to moderate reliability indicates a high degree of within-person variability, which presents challenges for designing well-powered epidemiological studies. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder