التفاصيل البيبلوغرافية
| العنوان: |
Molecular mechanisms of activitydependent changes in dendritic morphology: role of RGK proteins. |
| المؤلفون: |
Ghiretti, Amy E.1, Paradis, Suzanne1 paradis@brandeis.edu |
| المصدر: |
Trends in Neurosciences. Jul2014, Vol. 37 Issue 7, p399-407. 9p. |
| مصطلحات موضوعية: |
*MOLECULAR neurobiology, *DENDRITIC cells, *GTPASE-activating protein, *NEUROPLASTICITY, *CELLULAR signal transduction |
| مستخلص: |
The nervous system has the amazing capacity to transform sensory experience from the environment into changes in neuronal activity that, in turn, cause longlasting alterations in neuronal morphology. Recent findings indicate that, surprisingly, sensory experience concurrently activates molecular signaling pathways that both promote and inhibit dendritic complexity. Historically, a number of positive regulators of activitydependent dendritic complexity have been described, whereas the list of identified negative regulators of this process is much shorter. In recent years, there has been an emerging appreciation of the importance of the Rad/ Rem/Rem2/Gem/Kir (RGK) GTPases as mediators of activity-dependent structural plasticity. In the following review, we discuss the traditional view of RGK proteins, as well as our evolving understanding of the role of these proteins in instructing structural plasticity. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
