التفاصيل البيبلوغرافية
| العنوان: |
Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents. |
| المؤلفون: |
Yang, Seun-Ah1, Jung, Yeon-Seop2, Lee, Seung-Jin3, Park, Seung-Chun3, Kim, Min-Ju2, Lee, Eun-Ju2, Byun, Hae-Jung4, Jhee, Kwang-Hwan4, Lee, Sam-Pin1,2 splee@kmu.ac.kr |
| المصدر: |
Food & Chemical Toxicology. May2014, Vol. 67, p154-160. 7p. |
| مصطلحات موضوعية: |
*CELL death inhibition, *LACTATE dehydrogenase, *LIVER enzymes, *FERMENTATION, *UMBELLIFERAE, *PLANT extracts |
| مستخلص: |
Highlights: [•] Pretreatment with FDE of t-BHP-intoxicated HepG2 cells inhibited cell death and lactate dehydrogenase (LDH) leakage. [•] FDE significantly prevented the increase of hepatic enzyme markers (ALT, AST) in vivo. [•] FDE administration for 7days significantly affected gene expressions of CYP2E1, CYP4A2, and PPARγ. [•] Histopathological examination of the livers revealed that FDE reduced the incidence of liver lesions. [•] Caffeic acid and chlorogenic acid were identified as major constituents of FDE by HPLC, MS, and MS/MS techniques. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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