التفاصيل البيبلوغرافية
| العنوان: |
Matrix Metalloproteinase 7 Is Associated with Symptomatic Lesions and Adverse Events in Patients with Carotid Atherosclerosis. |
| المؤلفون: |
Abbas, Azhar1,2 azhar.abbas@ous-hf.no, Aukrust, Pål2,3,4, Russell, David1,4, Krohg-Sørensen, Kirsten5, Almås, Trine6, Bundgaard, Dorte7, Bjerkeli, Vigdis2,4, Sagen, Ellen Lund2,4, Michelsen, Annika E.2,4, Dahl, Tuva B.2,4, Holm, Sverre2, Ueland, Thor2,4, Skjelland, Mona1,2, Halvorsen, Bente2,4 |
| المصدر: |
PLoS ONE. Jan2014, Vol. 9 Issue 1, p1-8. 8p. |
| مصطلحات موضوعية: |
*MATRILYSIN, *PRECANCEROUS conditions, *ADVERSE health care events, *ATHEROSCLEROSIS, *CAROTID artery diseases, *IMMUNE system, *MOLECULAR genetics |
| مستخلص: |
Background: Atherosclerosis is a major cause of cerebrovascular disease. Matrix metalloproteinases (MMPs) play an important role in matrix degradation within the atherosclerotic lesion leading to plaque destabilization and ischemic stroke. We hypothesized that MMP-7 could be involved in this process. Methods: Plasma levels of MMP-7 were measured in 182 consecutive patients with moderate (50–69%) or severe (≥70%) internal carotid artery stenosis, and in 23 healthy controls. The mRNA levels of MMP-7 were measured in atherosclerotic carotid plaques with different symptomatology, and based on its localization to macrophages, the in vitro regulation of MMP-7 in primary monocytes was examined. Results: Our major findings were (i) Patients with carotid atherosclerosis had markedly increased plasma levels of MMP-7 compared to healthy controls, with particularly high levels in patients with recent symptoms (i.e., within the last 2 months). (ii) A similar pattern was found within carotid plaques with markedly higher mRNA levels of MMP-7 than in non-atherosclerotic vessels. Particularly high protein levels of MMP-7 levels were found in those with the most recent symptoms. (iii) Immunhistochemistry showed that MMP-7 was localized to macrophages, and in vitro studies in primary monocytes showed that the inflammatory cytokine tumor necrosis factor-α in combination with hypoxia and oxidized LDL markedly increased MMP-7 expression. (iv) During the follow-up of patients with carotid atherosclerosis, high plasma levels of MMP-7 were independently associated with total mortality. Conclusion: Our findings suggest that MMP-7 could contribute to plaque instability in carotid atherosclerosis, potentially involving macrophage-related mechanisms. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder